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Start Over Author "Di Rocco A" Journal child's nervous system
1,030 results on '"Di Rocco A"'

4. Intracranial complications of sinogenic and otogenic infections in children: an ESPN survey on their occurrence in the pre-COVID and post-COVID era

Author

Massimi, L., Cinalli, G., Frassanito, P., Arcangeli, V., Auer, C., Baro, V., Bartoli, A., Bianchi, F., Dietvorst, S., Di Rocco, F., Gallo, P., Giordano, F., Hinojosa, J., Iglesias, S., Jecko, V., Kahilogullari, G., Knerlich-Lukoschus, F., Laera, R., Locatelli, D., Luglietto, D., Luzi, M., Messing-Jünger, M., Mura, R., Ragazzi, P., Riffaud, L., Roth, J., Sagarribay, A., Pinheiro, M. Santos, Spazzapan, P., Spennato, P., Syrmos, N., Talamonti, G., Valentini, L., Van Veelen, M. L., Zucchelli, M., and Tamburrini, G.

Published
2024
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40. New insights in craniovertebral junction MR changes leading to stenosis in children with achondroplasia

Author

Sara Cabet, Alexandru Szathmari, Carmine Mottolese, Patricia Franco, Laurent Guibaud, Massimiliano Rossi, and Federico Di Rocco

Subjects
Radiography, Child, Preschool, Pediatrics, Perinatology and Child Health, Cervical Vertebrae, Humans, Female, Constriction, Pathologic, Foramen Magnum, Neurology (clinical), General Medicine, Child, Achondroplasia, Retrospective Studies
Abstract

To characterize natural history and early changes of craniovertebral junction stenosis in achondroplasia correlating with clinical and radiological outcome.Retrospective measures on craniovertebral junction were performed blindly, on sagittal T2-weighted images, in 21 patients with achondroplasia referred from 2008 to 2020. Clinical and polysomnography data were retrospectively collected. Each patient was paired for age and gender with four controls. Wilcoxon means comparison or Student's t-tests were applied.Twenty-one patients (11 females, from 0.1 to 39 years of age) were analyzed and paired with 84 controls. A craniovertebral junction stenosis was found in 11/21 patients (52.4%), all before the age of 2 years. Despite a significant reduction of the foramen magnum diameter (mean ± SD: patients 13.6 ± 6.2 mm, controls 28.5 ± 4.7 mm, p .001), craniovertebral junction stenosis resulted from the narrowing of C2 dens-opisthion antero-posterior diameter (8.7 ± 3.9 mm vs 24.6 ± 5.1 mm, p .001). Other significant changes were opisthion anterior placement (-0.4 ± 2.8 mm vs 9.4 ± 2.3 mm, p .001), posterior tilt of C2 (46.2 ± 13.7° vs 31.6 ± 7.9°, p .001) and of C1 (15.1 ± 4.3° vs 11.9 ± 5.0°, p = 0.01), and dens thickening (9.4 ± 2.2 mm vs 8.5 ± 2.1 mm, p = 0.03), allowing to define three distinguishable early craniovertebral junction patterns in achondroplasia. All children with C2-opisthion antero-posterior diameter of more than 6 mm had a better clinical and radiological outcome.Craniovertebral junction in achondroplasia results from narrowing between C2 dens and opisthion related to anterior placement of opisthion, thickening of C2 dens, and posterior tilt of C1-C2. A threshold of 6 mm for dens-opisthion sagittal diameter seems to correlate with clinical and radiological outcome.

Published
2022

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