It is essential for cross-regional control and treatment of major epidemics to establish a collaborative, efficient, and precise collective response mechanism. Based on the observation of the COVID-19 epidemic, this paper concludes major measures and experience of cross-regional collective response for epidemic control and treatment, compares the difference between localities at home and abroad, and puts forwards major strategies for a cross-regional collective response, hoping to provide policy-making references to improve the modernization level of public health, epidemic prevention, and emergency management in China. [ABSTRACT FROM AUTHOR]