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3 results on '"Cai, Linlin"'

1. One-pot tandem route to fused indolizidines and quinolizidines: Application in the synthesis of alkaloids and bioactive compounds

Author

Cai Linlin, Xinyu Cao, Liu Yan, Shan Qian, Wang Zhouyu, and Qiao Song

Subjects
Indolizidines, Tandem, Chemistry, Total synthesis, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Quinolizidines, 0104 chemical sciences, chemistry.chemical_compound, Amide, Organic chemistry, 0210 nano-technology
Abstract

Fused indolizidines and quinolizidines are important skeletons in a variety of natural products and pharmacologically important compounds. A one-pot tandem route from amide to fused indolizidines and quinolizidines is disclosed. This method is conducted in mild conditions and shows well tolerance of functional groups. It is also easy to be scaled up to gram scale and can be applied smoothly to the total synthesis of alkaloids such as (±)-crispine A, (±)-xylopinine, (±)-desbromoarborescidine A, (±)-harmicine and other bioactive substances.

Published
2021

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