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The base promoted three-component reaction of β-enamino imide, malononitrile and various cyclic α-diketones in acetonitrile showed interesting molecular diversity. The reactions with acenaphthylene-1,2-dione and ninhydrin afforded functionalized spiro[indene-2,4'-pyrrolo[3,4- b]pyridines] and spiro[acenaphthylene-1,4'-pyrrolo[3,4- b]pyridines] in good yields. The similar reaction of phenanthrene-9,10-dione resulted in the formation of the unexpected complex phenanthro[9',10':4,5]furo[2,3- c]pyrrolo[3,4- b]pyrroles in satisfactory yields. [ABSTRACT FROM AUTHOR]

The one-pot four-component reaction of benzohydrazide, acetylenedicarboxylate, aromatic aldehydes and malononitrile in ethanol with triethylamine as base catalyst afforded functionalized 1-benzamido-1,4-dihydropyridines in satisfactory yields. Under similar conditions, picolinohydrazide or nicotinohydrazide can also be successfully utilized in the reactions to give corresponding functionalized 1,4-dihydropyridines. 1H NMR data indicated that an equilibrium of cis/trans-conformations exist in 1-benzamido-1,4-dihydropyridines. [ABSTRACT FROM AUTHOR]