1. Cucurbit[ 7]uril-Based Vesicles Formed by Self-assembly of Supramolecular Amphiphiles.
- Author
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Li, Jiaxi, Zhou, Lipeng, Luo, Quan, Wang, Yongguo, Zhang, Chunqiu, Lu, Wei, Xu, Jiayun, and Liu, Junqiu
- Abstract
Cucurbituril (CB), a well-known macrocyclic cavitand, has been used extensively to construct supramolecular aggregates. Based on host-guest intertactions, an adamantanyl derivative guest molecule was designed and synthesized to prepare a supramolecular amphiphile with cucurbit[7]uril. In aqueous solution, the cucurbit[7]uril based supramolecular amphiphiles self-assemble into well-defined vesicles, and their disassembly can be achieved by addition of excess competitive agent 1-adamantanamine hydrochloride. This vesicle functions as a new nanocapsule to encapsulate molecules within its hollow cavity. Through competitive disassembly of supramolecular amphiphiles, the vesicles behave as a novel drug delivery carrier. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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