Search

Your search keyword '"Li, Xu-Wen"' showing total 4 results
Start Over Author "Li, Xu-Wen" Journal chinese journal of natural medicines
4 results on '"Li, Xu-Wen"'

4. Diversity-oriented synthesis of marine sponge derived hyrtioreticulins and their anti-inflammatory activities

Author

LI Xu-wen, Guo Yue-Wei, Pang Tao, Liu Jin, Chen Bo-Ru, Gao Cheng-Long, and Jiang Jian-Lan

Subjects
Drug, medicine.drug_class, media_common.quotation_subject, medicine.medical_treatment, Anti-Inflammatory Agents, Anti-inflammatory, Indole Alkaloids, Structure-Activity Relationship, Drug Discovery, medicine, Animals, media_common, Indole test, Biological Products, Pictet–Spengler reaction, Indole alkaloid, biology, Chemistry, Biological activity, General Medicine, biology.organism_classification, Porifera, Sponge, Cytokine, Complementary and alternative medicine, Biochemistry
Abstract

Diversity-oriented synthesis is aiming to increase the chemical diversity of the target natural products for extensive biological activity evaluation. Indole ring is an important functional group in a large number of drugs and other biologically active agents, and indole-containing natural products have been frequently isolated from marine sources in recent years. In this paper, a series of indole-containing marine natural hyrtioreticulin derivatives, including 19 new ones, were designed, synthesized via a key Pictet-Spengler reaction, and evaluated for their inflammation related activity. Compound 13b displayed the most promising activity by inhibiting TNF-α cytokine release with inhibitory rate of 92% at a concentration of 20 μM. A preliminary structure-activity relationship analysis was also discussed. This research may give an insight for the discovery of marine indole alkaloid derived anti-inflammatory drug leads.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results