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Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To study the changes in bone mineral density and bone metabolism in pregnant women with gestational diabetes mellitus(GDM) and the changes after drug intervention. Methods Bone metabolism and bone mineral density of GDM women who had been treated with calcitriol or did not undergo calcitriol intervention were compared. The indexes of bone metabolism assessed were as follows: 1,25-dihydroxyvitamin D [1,25-(OH)2-VD3], parathyroid hormone(PTH), bone gamma-carboxyglutamic-acid-containing proteins(BGP), procollagen type I carboxy-terminal peptide(PICP), glycated hemoglobin(hemoglobin A1 c, HbA1 c) and blood calcium(Ca). Bone mineral density was measured using ultrasound bone densitometer. Results There were significant differences in 1,25-(OH)2-VD3, BGP and PICP between GDM and GDM women supplemented with calcitriol in the second trimester of pregnancy and late pregnancy. There was a significant difference in bone mineral density in late pregnancy between GDM women and GDM women supplemented with calcitriol. There were no significant differences in blood levels of glucose and Ca between the two groups. Conclusion Calcitriol did not affect blood glucose level during pregnancy and could help to improve bone mineral density in pregnant women with GDM. [ABSTRACT FROM AUTHOR]

Objective To study the changes in bone mineral density and biochemical markers of bone metabolism in patients with subclinical hypothyroidism (SCH) during pregnancy. Methods Comparisons were made between normal pregnant women and pregnant women with subclinical hypothyroidism during pregnancy in bone mineral density，serum calcium (Ca)，serum magnesium (Mg)，serum phosphorus (P)，total cholesterol (TC)，triglyceride (TC)，total cholesterol (TC)，parathyroid hormone (PTH)， bone gamma-carboxyglutamic-acid-containing proteins (BGP)，and type I procollagen carboxy terminal peptides (PICP). Results The levels of P，TC，TG，PICP，BGP and bone mineral density were significantly different between pregnant women with SCH and normal pregnant women during the 1st trimester of pregnancy. Conclusion SCH during pregnancy can lead to decreased bone mineral density. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)