1. Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes.
- Author
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Zhang, Si, Xiao, Xi-Mian, Qi, Fan, Ma, Peng-Cheng, Zhang, Wei-Wei, Dai, Cheng-Zhi, Zhang, Dan-Feng, and Liu, Run-Hui
- Subjects
ACINETOBACTER baumannii ,BACTERIAL colonies ,GRAM-negative bacteria ,COLISTIN ,BROOMS & brushes ,PSEUDOMONAS aeruginosa ,ANTIBIOTICS - Abstract
Gram-negative bacteria can cause serious infections and are well known problems in biomedical practices. Biofilms of gram-negative bacteria are notorious for their frequently encountered resistance toward antibiotics. We demonstrate that α/β chimeric polypeptide molecular brush (α/β CPMB) exerts potent activities against antibiotic-resistant gram-negative bacteria. MTT viability assay, bacterial colony counting, and live/dead staining all indicate that α/β CPMB not only inhibits biofilm formation of gram-negative Pseudomonas aeruginosa and Acinetobacter baumannii, but also effectively disrupts mature biofilms that are highly resistant to one of the most active antibiotics—colistin. The superior antibacterial performance of the α/β CPMB implies its potential topical applications in treating biofilms. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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