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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: The development of tissue engineering is of great social and economic significance. Understanding the current status of basic research in this field can provide reference for developing corresponding development strategies. OBJECTIVE: To evaluate China's basic research current status in the field of tissue engineering. METHODS: A computer-based online search of Pubmed was performed to retrieve basic research papers and top papers in the field of tissue engineering using search terms MESH terms AND free-text word. In the context of global background, China’s ability of basic research in the field of tissue engineering was analyzed based on the number of papers, the growth of the number of papers, the number and proportion of top papers. In addition, the number of papers was used to identify the global research hotspots in the field of tissue engineering. RESULTS AND CONCLUSION: The top five countries in the field of tissue engineering were the United States, China, Japan, Germany and the United Kingdom. The total number of papers in this field published by Chinese scholars reached 17,031, second only to the United States. The compound annual growth rate of the number of papers was 19.9%, and the number of top papers was 195, ranking first and last among the top five countries, respectively. Eight Chinese institutions ranked top 30 in the number of papers in this field, with an average growth rate of 21.2%, far higher than that of all the top 30 institutions in the world (21.2% vs. 14.2, P < 0.001). However, Chinese institutions produced fewer top papers as compared to other top institutions, with the proportion of top papers significantly lower than that of the average level of the top 30 institutions (2.0% vs. 5.2%; P=0.002). There were five Chinese researchers whose total publications entered top 25 of the world. China's research in tissue engineering focuses on the areas of bone and cartilage, nerves, liver, skin, heart and eye tissue engineering, which is consistent with the global status. China's basic research in the field of tissue engineering ranks second in the world and expands rapidly in recent years. A number of academic institutions and individuals with great achievements have emerged. However, China's research quality in this field is relatively low as compared to other top institutions. It is suggested to guide researchers to pay more attention to the quality and transformation of research output, and to support the development of basic subjects such as material science to lay a good foundation for the development of tissue engineering in China. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Cartilage repair has always been a great challenge for orthopedic surgeons and also a hot issue in relevant fields. Recent studies have revealed the existence of cartilage progenitor cells with stem cell characteristics in the articular cartilage, providing a new entry point for cartilage repair. OBJECTIVE: By analyzing the trend of publications, author collaboration network, institutional collaboration network, co-occurrence analysis and clustering analysis of keywords in the cartilage progenitor cells-related literature, to explore the development status, research hotspots and difficulties in this field in the past 20 years, and to provide new ideas and directions for cartilage repair-related scientific research as well as clinical work. METHODS: The core ensemble database included in Web of Science 1999-2021 was used as the literature source, and Citespace 5.8.R1 was applied to visualize and analyze relevant literature and draw relevant visualization maps. RESULTS AND CONCLUSION: A total of 829 papers were included, and the analysis results showed that: the annual publication volume was basically stable at 30-50 articles with a slight downward trend; CHUANJU LIU had the most publications and the institution with the most publications was Harvard Univ; and there were 20 high-frequency keywords that formed 12 meaningful clusters. Mesenchymal stem cells, chondrocytes, osteoblasts, bone marrow stromal cells, and stromal cells are the current research hotspots. Cartilage precursor cells are currently of little research concern, and there is still great room for future exploration. Most of the current research on cartilage precursor cells focuses on the application of tissue engineering materials combined with the cells for cartilage defect repair. Current frontier hotspots in cartilage repair research include the sources of chondrocytes and cartilage precursor cells, application of exosomes, tissue-scaffold interactions and scaffold degradation, identification and application of new stimuli, understanding structural maturation, biomechanics and function, and improving implantation, fixation and rehabilitation methods. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Mechanisms undelying diagnosis and treatment of arthritis can be analyzed by metabonomics to study the metabolites. The combination of metabonomics and bibliometrics can systematically clarify the research status of osteoarthritis. OBJECTIVE: To analyze and summarize the research status of metabonimics in arthritis, and to prospect the future tendency. METHODS: CNKI, VIP, WanFang, CBM, PubMed, EBSCO, Web of Science and Elsevier databases were searched for the articles addressing the metabonimics in arthritis published before May 2017. The keywords were “metabolomics and arthritis” in English and Chinese, respectively. Initially 201 articles were retrieved, and finally 59 articles were included based on the inclusion and exclusion criteria for basic information and result analysis. RESULTS AND CONCLUSION: (1) Literature of metabonomics on arthritis began to be reported from 2007, and the number of literature increased with time. (2) The first author’s affiliations were concentrated in universities 37(63%), hospitals 15 (25%) and institutes 7 (12%). (3) The articles included 44 articles from journals (75%), 12 dissertation (19%), 4 conference papers (7%), and the 44 papers were published in 38 kinds of journals. (4) Totally 36 articles were funded, 29 articles (49%) funded by the National Natural Science Foundation, 18 (31%) funded by department-level foundation, 10 (17%) funded by provincial foundation, 5 (8%) foreign foundation and 5 (8%) funded by school foundation. (5) The types of arthritis were mainly rheumatoid arthritis 40 (68%), osteoarthritis 7 (12%), gouty arthritis 6 (10%) and others 6 (10%). (6) The main research directions were metabonomis on treatment effectiveness 30 (51%), pathogenesis of arthritis 17 (29%), Chinese medicine syndromes 6 (10%) and research progress 6 (10%). (7) Metabolomics samples in the literature included the body fluid samples 53 (90%) and tissue samples 6 (10%). (8) Metabonomics analysis techniques included liquid chromatography-mass spectrometry 33 (56%), nuclear magnetic resonance technology 15 (25%), gas chromatography-mass spectrometry 10 (17%), NMR combined with GC-MS 1 (2%). In summary, metabonomics has been extensively applied in arthritis and has been an issue of concern. Understanding the side events in Chinese medicines for arthritis based on metabonomics can provide reference for the following prospective study and clinical application. [ABSTRACT FROM AUTHOR]

BACKGROUND: Cartilage repair has always been a great challenge for orthopedics doctors all over the world, and it has always been a research hot-spot. OBJECTIVE: To explore the development status, research hotspots and dynamic frontiers in cartilage repair in the past 15 years based on the bibliometric, co-occurrence, co-citation and visual analysis of relevant literature. METHODS: Based on the core collection of related documents in the Web of Science (WOS) database from January 1, 2006 to April 6, 2020, CiteSpace software was used for a literature visual analysis. RESULTS AND CONCLUSION: A total of 1 632 papers were included. The results of co-occurrence analysis, burst analysis and cluster analysis show that cartilage repair belongs to the field of regenerative medicine, and the types of stem cells mainly involved in cell transplantation include human bone marrow mesenchymal stem cells, mesenchymal stem cells, artificial multi-functional stem cells, adipose tissue derived stem cells. It can be seen that stem cells are the research focus in the past, present or future. Treatments for cartilage repair include autograft chondrocyte transplantation, mosaic plasty, tissue-engineered cartilage implantation, intraarticular administration, combined gene transfer, which are widely used at present. Factors influencing gene expression include overexpressed human fibroblast growth factor, expanded chondrocytes, sulfur oxide 9, recombinant adeno-associated virus, γ- glutamic acid, cetylpyridinium chloride, mechanical properties, and telomerase activity. These biocompatible materials and factors of culture medium can guide gene carriers in cartilage repair, which is a hot topic in the future. Tissue engineering technology such as polycaprolactone membrane, polyglycolic acid keratin hydrogel and other tissue engineering materials used for mesenchymal stem cell transplantation is the current research trend. The above results show that through the application of CiteSpace software for bibliometric and visual analysis, we can intuitively see the development of cartilage repair in the past 15 years, mainly revealing that stem cell therapy for cartilage defects, different biocompatible materials and different gene transfer technologies for cartilage repair are the current research hots and the developmental trends of cartilage repair, providing different ideas and research directions of animal experiments and clinical trials for domestic scientific research and clinical workers. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)