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Objective: To investigate the prevalence，and the factors that influence depressive symptoms a- mong chronic respiratory disease patients in tertiary hospital Methods: A total of 1713 outpatients and inpatients with chronic respiratory disease were selected from 8 tertiary hospitals in Jiangsu Province from July to September, 2014 and screened according to the Hospital Anxiety Depression Scale-D (HADS-D). A questionnaire developed by this research group, was used to collect demographic and clinical information. Logistic regression was used to identi­fy factors that were associated with depressive symptoms. Results: The overall rate of depressive symptoms was 46. 0%. Multiple logistic analysis showed that spinsterhood (OR =0.45), higher education level (middle school / high school/technical school OR =0. 65; college degree or aboweOR = Q. 28), BMI ⩾24 (OR = 0. 71) were associat­ed with decreased risk of depressive symptoms (P <0. 05). BMI < 18. 5 (OR = 1. 52,), average income of family ⩾10000 RMB (OR = 1.37 -1. 96), limited daily activities (OR = 1. 72), poorer sleep quality (OR = 1. 45), and negative life events (OR = L 62) were associated with increased risk of depressive symptoms (P <0. 05). Conclusion: The prevalence of depressive symptoms among chronic respiratory disease patients in tertiary hospitals in Jiangsu Province was higher. Marital status, education level, income, BMI, limited daily activities, subjective sleep quality, negative life events may be the related factors of depressive symptoms of chronic respiratory diseases patients. [ABSTRACT FROM AUTHOR]