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Your search keyword '"Qingqing Gao"' showing total 3 results
Start Over Author "Qingqing Gao" Journal chinese physics b
3 results on '"Qingqing Gao"'

1. Effect of particle shape on the packing fraction and velocity profiles at the outlet of a silo

Author

Qingqing Gao, Yuchao Chen, and Lin Hu

Subjects
General Physics and Astronomy
Abstract

Many studies on how the particle shape affects the discharge flow mainly focus on discharge rates and avalanche statistics. In this study, the effect of the particle shape on the packing fractions and velocities of particles in the silo discharge flow was investigated by using discrete element method. The time-averaged packing fraction and velocity profiles through the aperture were systematically measured for superelliptical particles with different blockiness. Increasing the particle blockiness is found to increase resistance to flow and reduces the flow rate. At an identical outlet size, larger particle blockiness leads to lower velocities and packing fractions at the outlet. The packing fraction profiles display evident self-similar features that can be appropriately adjusted by fractional power laws. The velocity profiles for particles with different shapes obey a uniform self-similar law that is in accord with previous experimental results, which is compatible with the free fall arch hypothesis. To further investigate the origin of flow behaviors, the packing fraction and velocity fields in the region above the orifice were computed. Based on these observations, the flow rate of superelliptical particles was calculated and agrees with the simulated data.

Published
2022

2. Enhanced effect of dimension of receptor-ligand complex and depletion effect on receptor-mediated endocytosis of nanoparticles

Author

Chuang Zhao, Zongliang Mao, Yijun Liu, Qingqing Gao, Yanhui Liu, Ye Liu, and Lin Hu

Subjects
Dimension (vector space), Chemistry, 0103 physical sciences, Biophysics, General Physics and Astronomy, Nanoparticle, 02 engineering and technology, Receptor-mediated endocytosis, Receptor-ligand complex, 021001 nanoscience & nanotechnology, 010306 general physics, 0210 nano-technology, 01 natural sciences
Published
2017

3. Enhanced effect of dimension of receptor-ligand complex and depletion effect on receptor-mediated endocytosis of nanoparticles.

Author

Ye Liu, Qingqing Gao, Yijun Liu, Chuang Zhao, Zongliang Mao, Lin Hu, and Yanhui Liu

Subjects
*NANOPARTICLES, *ENDOCYTOSIS, *LIGANDS (Chemistry), *PHASE diagrams, *DIFFUSION
Abstract

We present an extended analytical model including the depletion effect and the dimension of ligand-receptor complex, aiming to elucidate their influences on endocytosis of spherocylindrical nanoparticles (NPs). It is found that the dimension of ligand-receptor complex (δ) and the depletion effect interrelatedly govern the optimal conditions of NP endocytosis. The endocytosis phase diagram constructed in the space of NP radius and relative aspect ratio indicates that the endocytosis of NP is enhanced evidently by reducing the optimal radius and the threshold radius of endocytosed NP. Meanwhile, through thermodynamic and kinetic analysis of the diffusion of receptors, the dependence of diffusion length on depletion effect and the dimension of ligand-receptor complex can be identified in great detail. For small aspect ratio, diffusion length decreases with increasing concentration c of small bioparticles in cellular environment. Endocytosis speed corresponding to large radius R and high concentration c of small bioparticles strongly depends on the increasing . These results may show some highlights into the conscious design of NPs for diagnostic agents and therapeutic drug delivery applications. [ABSTRACT FROM AUTHOR]

Published
2017
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