1. Role of Tip60 tumor suppressor in DNA repair pathway.
- Author
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LIU ZhiJian and SUN YingLi
- Subjects
- *
DNA repair , *DNA damage , *EUKARYOTIC cells , *ACETYLTRANSFERASES , *ATAXIA telangiectasia , *METHYLATION , *ANTIMUTAGENS - Abstract
To prevent the damage caused by DNA strand breaks, eukaryotic cells have evolved a series of highly conserved DNA repair mechanisms. The ubiquitously expressed acetyltransferase, Tip60, plays a central role in ATM (ataxia-telangiectasia mutated) activation which is involved in DNA repair. Recent work uncovered a new mechanism of ATM activation mediated by Tip60 and demonstrated that histone methylation, specifically, trimethylation of histone H3, is a key factor in the process. Here, we review the current understanding of how Tip60 is activated and how it activates ATM in response to DNA damage. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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