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This paper presents a 457-year reconstruction of precipitation in the southeastern Qinghai-Tibet Plateau using tree-ring records. Tree-ring samples were collected from the Hengduan Mountains in the southeastern part of the Qinghai-Tibet Plateau, China. A nearly 500-year chronology was developed using tree-ring width records. Correlation analysis shows moisture is the main factor limiting tree growth in this region. Ring-widths were significantly positively correlated with the Palmer Drought Severity Index (PDSI) and precipitation in many months. The highest correlation coefficient was found between the annual growth of trees and precipitation from the previous September to the current June (0.738). Based on this relationship, we reconstructed the precipitation history from 1509 to 2006. The reconstruction explains 54.4% ( R=53.5%, N=49, F=56.12) of the actual precipitation variation during the calibration period (1958-2006). During the reliable period of the reconstruction (1549-2006), some low-frequency climate signals are included, indicating this region has been getting wetter in the last 20 years. The reconstruction documents six apparently dry and five pluvial periods and the 17th century dry period lasted longer than any other. When compared with other recent studies, this study and these earlier reconstructions show a similar trend in the variation of drought and pluvial. Further spatial correlation analysis confirms that the reconstructed precipitation adequately represents the rainfall history of the entire Hengduan Mountain area. The Multi-taper method, a type of spectral analysis, reveals that precipitation in this area had significant ( P<0.01) spectral peaks at 3-5 a, 60 a and 79-85 a. [ABSTRACT FROM AUTHOR]