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A novel high-intensity TiO nanotubes array membrane was fabricated via electrochemical anodization of highly pure titanium foil and an open-ended TiO nanotubes array membrane was obtained by HF gas etching at the bottom of the nanotubes. Pig tubular epithelial cells (LLC-PK1) and vascular endothelial cells (ECV304) were cultivated on the open-ended TiO nanotubes surface through a mixing implantation method and TiO nanotubes biomembrane materials with physiological function were successfully produced. Hemocompatibility of glass slides, pure titanium, TiO nanotubes without cells and TiO nanotubes with culture cells were investigated by the plasma recalcification time method and reabsorption of sodium and potassium were measured by custom-designed devices. The results show that the hemocompatibility of the TiO nanotubes array membrane with culture cells was superior to the control group, and the biomembrane has an excellent reabsorption function. This demonstrates that a TiO nanotubes array membrane has excellent physiological function and is an ideal candidate material for biological dialysis. [ABSTRACT FROM AUTHOR]

Biomembrane-coated capillaries are prepared by coating different kinds of biomembranes including mice red cell membrane, human red cell membrane and S-180 cell membrane on the inner surface of the capillary, respectively. Effects of immobilized biomembrane amount, pH and biomembrane species on the interactions between drugs and biomembranes have been evaluated. The results showed that the chromatographic retention factor for each drug was essentially related to the amount of immobilized biomembrane, the pH and the type of biomembrane. [ABSTRACT FROM AUTHOR]