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The calibration accuracy declines when there is relative location change between the camera and the integrating sphere in the process of non-uniformity calibration. A new method of relative radiometric calibration using multi-position fused data was proposed. To eliminate the shortcoming of angular and facial non-uniformity of the integrating sphere, the calibration coefficients were obtained by a lot of images from multi-positions. Experiment results show that the proposed method can decrease the effect of non-uniformity of the sphere light intensity on the calibration coefficients, under the condition that the light intensity of the integrating sphere is uneven and the relative position between the camera and the sphere can not be fixed. This new method can improve the non-uniformity calibration accuracy. [ABSTRACT FROM AUTHOR]