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BACKGROUND: The Self-Care of Coronary Heart Disease Inventory -Patient Version 3 (SC-CHDI v3) is a globally used tool for assessing self-care behaviors among patients with coronary heart disease (CHD). This study aimed to translate the SC-CHDI v3 into Farsi, validate it, and evaluate its psychometric properties among Iranian patients. METHODS: The translation of the original SC-CHDI v3 into Farsi was conducted in 2022 at Shaheed Rajaie Cardiovascular, Medical & Research Center, Tehran, Iran, following a standard forward-backward approach. The validation process included face, content, and construct validity. A panel of 10 experts scored each item's necessity on an ordinal Likert scale of three. The content validity ratio (CVR) was computed using the Lawshe formula. Ten judges from the predefined panel rated each item on a 4-point Likert scale regarding relevancy, clarity, and simplicity for individual CVI calculation. The mean individual-CVI was used to determine the Scale-CVI for each domain. Questions with minimum values of CVR and CVI were retained for reliability evaluation. Construct validity was assessed through confirmatory factor analysis. Internal consistency reliability was evaluated using Cronbach's α and McDonald's Omega. Test-retest reliability was determined using intraclass correlation coefficients (ICC). RESULTS: All questions achieved CVR values exceeding 0.62 and CVI scores of 0.80 or higher, and thus were retained in the questionnaire. Face validity evaluation indicated that all questions were deemed acceptable in terms of relevance and clarity. Cronbach's α coefficients for self-care maintenance and monitoring were 0.802 and 0.817, respectively, while McDonald's Omega for the self-care management scale was 0.725. The ICC was 0.81, demonstrating good test-retest reliability. Confirmatory factor analysis revealed relative goodness of fit for all dimensions. CONCLUSION: The Farsi version of the SC-CHDI v3 proved to be a reliable tool for assessing self-care behaviors among Iranian CHD patients, enabling healthcare professionals to develop personalized self-care