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Your search keyword '"Schott, Jean-Jacques"' showing total 10 results
Start Over Author "Schott, Jean-Jacques" Journal circulation: cardiovascular genetics
10 results on '"Schott, Jean-Jacques"'

1. Search for Rare Copy-Number Variants in Congenital Heart Defects Identifies Novel Candidate Genes and a Potential Role for FOXC1 in Patients With Coarctation of the Aorta

Author

Sanchez-Castro, Marta, primary, Eldjouzi, Hadja, additional, Charpentier, Eric, additional, Busson, Pierre-François, additional, Hauet, Quentin, additional, Lindenbaum, Pierre, additional, Delasalle-Guyomarch, Béatrice, additional, Baudry, Adrien, additional, Pichon, Olivier, additional, Pascal, Cécile, additional, Lefort, Bruno, additional, Bajolle, Fanny, additional, Pezard, Philippe, additional, Schott, Jean-Jacques, additional, Dina, Christian, additional, Redon, Richard, additional, Gournay, Véronique, additional, Bonnet, Damien, additional, and Le Caignec, Cédric, additional

Published
2016
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2. Genetic Association Analyses Highlight IL6, ALPL, and NAV1As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis

Author

Thériault, Sébastien, Dina, Christian, Messika-Zeitoun, David, Le Scouarnec, Solena, Capoulade, Romain, Gaudreault, Nathalie, Rigade, Sidwell, Li, Zhonglin, Simonet, Floriane, Lamontagne, Maxime, Clavel, Marie-Annick, Arsenault, Benoit J., Boureau, Anne-Sophie, Lecointe, Simon, Baron, Estelle, Bonnaud, Stéphanie, Karakachoff, Matilde, Charpentier, Eric, Fellah, Imen, Roussel, Jean-Christian, Philippe Verhoye, Jean, Baufreton, Christophe, Probst, Vincent, Roussel, Ronan, Redon, Richard, Dagenais, François, Pibarot, Philippe, Mathieu, Patrick, Le Tourneau, Thierry, Bossé, Yohan, Schott, Jean-Jacques, Balkau, B., Ducimetière, P., Eschwège, E., Alhenc-Gelas, F., Girault, A., Fumeron, F., Marre, M., Bonnet, F., Bonnefond, A., Froguel, P., Rancière, F., Cogneau, J., Born, C., Caces, E., Cailleau, M., Lantieri, O, Moreau, J.G., Rakotozafy, F., Tichet, J., and Vol, S.

Abstract

Supplemental Digital Content is available in the text.

Published
2019
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3. Analysis for Genetic Modifiers of Disease Severity in Patients With Long-QT Syndrome Type 2

Author

Kolder, Iris C.R.M., primary, Tanck, Michael W.T., additional, Postema, Pieter G., additional, Barc, Julien, additional, Sinner, Moritz F., additional, Zumhagen, Sven, additional, Husemann, Anja, additional, Stallmeyer, Birgit, additional, Koopmann, Tamara T., additional, Hofman, Nynke, additional, Pfeufer, Arne, additional, Lichtner, Peter, additional, Meitinger, Thomas, additional, Beckmann, Britt M., additional, Myerburg, Robert J., additional, Bishopric, Nanette H., additional, Roden, Dan M., additional, Kääb, Stefan, additional, Wilde, Arthur A.M., additional, Schott, Jean-Jacques, additional, Schulze-Bahr, Eric, additional, and Bezzina, Connie R., additional

Published
2015
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4. A Large Candidate Gene Survey Identifies the KCNE1 D85N Polymorphism as a Possible Modulator of Drug-Induced Torsades de Pointes

Author

Kääb, Stefan, primary, Crawford, Dana C., additional, Sinner, Moritz F., additional, Behr, Elijah R., additional, Kannankeril, Prince J., additional, Wilde, Arthur A.M., additional, Bezzina, Connie R., additional, Schulze-Bahr, Eric, additional, Guicheney, Pascale, additional, Bishopric, Nanette H., additional, Myerburg, Robert J., additional, Schott, Jean-Jacques, additional, Pfeufer, Arne, additional, Beckmann, Britt-Maria, additional, Martens, Eimo, additional, Zhang, Taifang, additional, Stallmeyer, Birgit, additional, Zumhagen, Sven, additional, Denjoy, Isabelle, additional, Bardai, Abdennasser, additional, Van Gelder, Isabelle C., additional, Jamshidi, Yalda, additional, Dalageorgou, Chrysoula, additional, Marshall, Vanessa, additional, Jeffery, Steve, additional, Shakir, Saad, additional, Camm, A. John, additional, Steinbeck, Gerhard, additional, Perz, Siegfried, additional, Lichtner, Peter, additional, Meitinger, Thomas, additional, Peters, Annette, additional, Wichmann, H.-Erich, additional, Ingram, Christiana, additional, Bradford, Yuki, additional, Carter, Shannon, additional, Norris, Kris, additional, Ritchie, Marylyn D., additional, George, Alfred L., additional, and Roden, Dan M., additional

Published
2012
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5. Response to the Letter by Kattygnarath et al

Author

Kattygnarath, Darouna, primary, Maugenre, Svetlana, additional, Neyroud, Nathalie, additional, Balse, Elise, additional, Ichai, Carole, additional, Denjoy, Isabelle, additional, Dilanian, Gilles, additional, Martins, Raphaël P., additional, Fressart, Véronique, additional, Berthet, Myriam, additional, Schott, Jean Jacques, additional, Leenhardt, Antoine, additional, Probst, Vincent, additional, Le Marec, Hervé, additional, Hainque, Bernard, additional, Coulombe, Alain, additional, Hatem, Stéphane N., additional, and Guicheney, Pascale, additional

Published
2011
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6. MOG1

Author

Kattygnarath, Darouna, primary, Maugenre, Svetlana, additional, Neyroud, Nathalie, additional, Balse, Elise, additional, Ichai, Carole, additional, Denjoy, Isabelle, additional, Dilanian, Gilles, additional, Martins, Raphaël P., additional, Fressart, Véronique, additional, Berthet, Myriam, additional, Schott, Jean Jacques, additional, Leenhardt, Antoine, additional, Probst, Vincent, additional, Le Marec, Hervé, additional, Hainque, Bernard, additional, Coulombe, Alain, additional, Hatem, Stéphane N., additional, and Guicheney, Pascale, additional

Published
2011
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7. SCN5A Mutations and the Role of Genetic Background in the Pathophysiology of Brugada Syndrome

Author

Probst, Vincent, primary, Wilde, Arthur A.M., additional, Barc, Julien, additional, Sacher, Frederic, additional, Babuty, Dominique, additional, Mabo, Philippe, additional, Mansourati, Jacques, additional, Le Scouarnec, Solena, additional, Kyndt, Florence, additional, Le Caignec, Cedric, additional, Guicheney, Pascale, additional, Gouas, Laetitia, additional, Albuisson, Juliette, additional, Meregalli, Paola G., additional, Le Marec, Hervé, additional, Tan, Hanno L., additional, and Schott, Jean-Jacques, additional

Published
2009
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8. Analysis for Genetic Modifiers of Disease Severity in Patients With Long-QT Syndrome Type 2.

Author

Postema, Pieter G., Koopmann, Tamara T., Kolder, Iris C. R. M., Bezzina, Connie R., Wilde, Arthur A. M., Barc, Julien, Hofman, Nynke, Pfeufer, Arne, Lichtner, Peter, Meitinger, Thomas, Myerburg, Robert J., Bishopric, Nanette H., Roden, Dan M., Tanck, Michael W. T., Schott, Jean-Jacques, Sinner, Moritz F., Beckmann, Britt M., Kääb, Stefan, Zumhagen, Sven, and Husemann, Anja

Subjects
LONG QT syndrome, ION channels, ARRHYTHMIA, GENETICS
Abstract

Background--Considerable interest exists in the identification of genetic modifiers of disease severity in the long-QT syndrome (LQTS) as their identification may contribute to refinement of risk stratification. Methods and Results--We searched for single-nucleotide polymorphisms (SNPs) that modulate the corrected QT (QTc)- interval and the occurrence of cardiac events in 639 patients harboring different mutations in KCNH2. We analyzed 1201 SNPs in and around 18 candidate genes, and in another approach investigated 22 independent SNPs previously identified as modulators of QTc-interval in genome-wide association studies in the general population. In an analysis for quantitative effects on the QTc-interval, 3 independent SNPs at NOS1AP (rs10494366, P=9.5×10-8; rs12143842, P=4.8×10-7; and rs2880058, P=8.6×10-7) were strongly associated with the QTc-interval with marked effects (>12 ms/allele). Analysis of patients versus general population controls uncovered enrichment of QTc-prolonging alleles in patients for 2 SNPs, located respectively at NOS1AP (rs12029454; odds ratio, 1.85; 95% confidence interval, 1.32-2.59; P=3×10-4) and KCNQ1 (rs12576239; odds ratio, 1.84; 95% confidence interval, 1.31-2.60; P=5×10-4). An analysis of the cumulative effect of the 6 NOS1AP SNPs by means of a multilocus genetic risk score (GRSNOS1AP) uncovered a strong linear relationship between GRSNOS1AP and the QTc-interval (P=4.2×10-7). Furthermore, patients with a GRSNOS1AP in the lowest quartile had a lower relative risk of cardiac events compared with patients in the other quartiles combined (P=0.039). Conclusions--We uncovered unexpectedly large effects of NOS1AP SNPs on the QTc-interval and a trend for effects on risk of cardiac events. For the first time, we linked common genetic variation at KCNQ1 with risk of long-QT syndrome. [ABSTRACT FROM AUTHOR]

Published
2015
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9. A Large Candidate Gene Survey Identifies the KCNE1D85N Polymorphism as a Possible Modulator of Drug-Induced Torsades de Pointes

Author

Kääb, Stefan, Crawford, Dana C., Sinner, Moritz F., Behr, Elijah R., Kannankeril, Prince J., Wilde, Arthur A.M., Bezzina, Connie R., Schulze-Bahr, Eric, Guicheney, Pascale, Bishopric, Nanette H., Myerburg, Robert J., Schott, Jean-Jacques, Pfeufer, Arne, Beckmann, Britt-Maria, Martens, Eimo, Zhang, Taifang, Stallmeyer, Birgit, Zumhagen, Sven, Denjoy, Isabelle, Bardai, Abdennasser, Gelder, Isabelle C. Van, Jamshidi, Yalda, Dalageorgou, Chrysoula, Marshall, Vanessa, Jeffery, Steve, Shakir, Saad, Camm, A. John, Steinbeck, Gerhard, Perz, Siegfried, Lichtner, Peter, Meitinger, Thomas, Peters, Annette, Wichmann, H.-Erich, Ingram, Christiana, Bradford, Yuki, Carter, Shannon, Norris, Kris, Ritchie, Marylyn D., George, Alfred L., and Roden, Dan M.

Abstract

Drug-induced long-QT syndrome (diLQTS) is an adverse drug effect that has an important impact on drug use, development, and regulation. We tested the hypothesis that common variants in key genes controlling cardiac electric properties modify the risk of diLQTS.

Published
2012
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10. Genome-Wide Association Study–Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1as a Susceptibility Gene for Mitral Valve Prolapse

Author

Yu, Mengyao, Georges, Adrien, Tucker, Nathan R., Kyryachenko, Sergiy, Toomer, Katelyn, Schott, Jean-Jacques, Delling, Francesca N., Fernandez-Friera, Leticia, Solis, Jorge, Ellinor, Patrick T., Levine, Robert A., Slaugenhaupt, Susan A., Hagège, Albert A., Dina, Christian, Jeunemaitre, Xavier, Milan, David J., Norris, Russell A., and Bouatia-Naji, Nabila

Abstract

Supplemental Digital Content is available in the text.

Published
2019
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