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Introduction: Asians are the most rapidly growing minority population in the United States, yet coronary artery disease (CAD) treatment and outcomes among Asian subgroups remain poorly understood. Methods: We analyzed 772,882 patients receiving care from the Palo Alto Medical Foundation from 2006-2015 to determine whether CAD treatment and outcomes differ by race, including Asian subgroups, with adjustment for age, gender, household income and comorbidities. Results: Among the cohort, 219,150 patients were Asian (38.5% Asian Indian, 28.4% Chinese, 9.6% Filipino, 4.2% Japanese, 3.2% Korean, 2.1% Vietnamese, and 14.1% "Other Asian"). Among those who received angiogram, prevalence of CAD was highest among Asian Indian (81.3%), Chinese (83.3%), and Filipinos (82.4%). Compared to Non-Hispanic Whites (NHW), Chinese were more likely to receive a stent (50.9% vs 60.8%, adj OR 1.4 [95% CI 1.0 - 1.9], p = 0.005), while Filipinos were more likely to undergo CABG (6.9% vs 20.5%, adjusted OR 2.7 [CI 1.9 - 4.0], p <0.0001). After stenting, Chinese, Filipinos, and Japanese were more likely to be prescribed clopidogrel compared to NHW (86.2%, 83.0%, and 91.4% vs 74.5%, adj ORs 1.8 [CI 1.1 - 3.0], 1.9 [CI 1.0 - 3.4], and 4.4 [CI 1.0 - 18.7] respectively, p <0.0001) but there were no significant differences in prasugrel prescription by race. There were no significant differences by race in post-angiogram 1-year mortality, stroke, transient ischemic attack, or bleeding. However, Chinese and Asian Indians were more likely to be diagnosed with a myocardial infarction within 1 year following coronary angiography compared to NHW (15.6% and 17.4% vs 11.2%, adj ORs 1.5 [CI 1.0 - 2.2] and 1.7 [CI 1.2 - 2.3] respectively, p <0.0001, see Figure). Conclusions: Disaggregation reveals significant diversity in CAD treatments and outcomes by Asian subgroup, highlighting potential opportunities to meet the needs of growing Asian populations in the United States. [ABSTRACT FROM AUTHOR]