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Ischemic heart disease (IHD) affects over 48 million women in the US and is the leading cause of death. Hypertension, diabetes and dyslipidemia are risk factors for the genesis of IHD in women. Disease management programs (DM) have proven effective, overall, in facilitating lifestyle change and adherence to treatment plan but little is known about the effectiveness of these programs for men versus women. The purpose of this program evaluation was to identify differences in outcomes between men and women who participated in DM programs for hypertension, diabetes and dyslipidemia.Between 2015 and 2019, 616 unique individuals completed one of these DM programs. Measures of height, weight, exercise minutes, sedentary lifestyle, healthy nutrition, sleep, hydration and medication adherence were taken at the first and last visit. The sample was primarily female (70%), white (76%), Married (67%), educated (93% had bachelor’s or better), and were 49.3 years old, on average. Analysis revealed that males and females differ in response to the DM programs. While there was significant decrease in BMI for all participants (p