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Your search keyword '"Esposito, Bruno"' showing total 12 results
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12 results on '"Esposito, Bruno"'

1. Abstract 5164: Loss of SOCS3 Expression in T Cells Reveals a Regulatory Role for Interleukin-17 in Atherosclerosis

Author

Taleb, Soraya, primary, Romain, Melissa, additional, Ramkhelawon, Bhama, additional, Uyttenhove, Catherine, additional, Pasterkamp, Gerard, additional, Herbin, Olivier, additional, Esposito, Bruno, additional, Perez, Nicolas, additional, Yasukawa, Hideo, additional, van Snick, Jacques, additional, Yoshimura, Akihiko, additional, Tedgui, Alain, additional, and Mallat, Ziad, additional

Published
2009
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2. Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

Author

Combadière, Christophe, primary, Potteaux, Stéphane, additional, Rodero, Mathieu, additional, Simon, Tabassome, additional, Pezard, Adeline, additional, Esposito, Bruno, additional, Merval, Régine, additional, Proudfoot, Amanda, additional, Tedgui, Alain, additional, and Mallat, Ziad, additional

Published
2008
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3. Abstract 876: Combined Inhibition Of Ccl2, Cx3cr1 And Ccr5 Abrogates Ly6chi And Ly6clo Monocytosis And Almost Abolishes Atherosclerosis In Hypercholesterolemic Mice

Author

Potteaux, Stephane, primary, Combadiere, Christophe, additional, Pezard, Adeline, additional, Riou, Stephanie, additional, Simon, Tabassome, additional, Rodero, Mathieu, additional, Esposito, Bruno, additional, Merval, Regine, additional, Proudfoot, Amanda, additional, Lehoux, Stephanie, additional, Tedgui, Alain, additional, and Mallat, Ziad, additional

Published
2007
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5. Lactadherin Deficiency Leads to Apoptotic Cell Accumulation and Accelerated Atherosclerosis in Mice

Author

Ait-Oufella, Hafid, primary, Kinugawa, Kiyoka, additional, Zoll, Joffrey, additional, Simon, Tabassome, additional, Boddaert, Jacques, additional, Heeneman, Silvia, additional, Blanc-Brude, Olivier, additional, Barateau, Véronique, additional, Potteaux, Stéphane, additional, Merval, Régine, additional, Esposito, Bruno, additional, Teissier, Elisabeth, additional, Daemen, Mat J., additional, Lesèche, Guy, additional, Boulanger, Chantal, additional, Tedgui, Alain, additional, and Mallat, Ziad, additional

Published
2007
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8. Transplantation of Bone Marrow–Derived Mononuclear Cells in Ischemic Apolipoprotein E–Knockout Mice Accelerates Atherosclerosis Without Altering Plaque Composition

Author

Silvestre, Jean-Sébastien, primary, Gojova, Andrea, additional, Brun, Valérie, additional, Potteaux, Stéphane, additional, Esposito, Bruno, additional, Duriez, Micheline, additional, Clergue, Michel, additional, Le Ricousse-Roussanne, Sophie, additional, Barateau, Véronique, additional, Merval, Régine, additional, Groux, Hervé, additional, Tobelem, Gérard, additional, Levy, Bernard, additional, Tedgui, Alain, additional, and Mallat, Ziad, additional

Published
2003
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11. Severe Atherosclerosis and Hypoalphalipoproteinemia in the Staggerer Mouse, a Mutant of the Nuclear Receptor RORα

Author

Mamontova, Anna, primary, Séguret-Macé, Sandrine, additional, Esposito, Bruno, additional, Chaniale, Colette, additional, Bouly, Muriel, additional, Delhaye-Bouchaud, Nicole, additional, Luc, Gérald, additional, Staels, Bart, additional, Duverger, Nicolas, additional, Mariani, Jean, additional, and Tedgui, Alain, additional

Published
1998
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12. Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6C(hi) and Ly6C(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice.

Author

Combadière C, Potteaux S, Rodero M, Simon T, Pezard A, Esposito B, Merval R, Proudfoot A, Tedgui A, and Mallat Z

Subjects
Animals, Atherosclerosis genetics, Atherosclerosis metabolism, CCR5 Receptor Antagonists, CX3C Chemokine Receptor 1, Chemokine CCL2 antagonists & inhibitors, Chemokine CCL2 physiology, Hypercholesterolemia metabolism, Hypercholesterolemia pathology, Macrophages metabolism, Macrophages pathology, Male, Mice, Mice, Knockout, Receptors, CCR5 physiology, Receptors, Chemokine antagonists & inhibitors, Receptors, Chemokine physiology, Signal Transduction immunology, Antigens, Ly biosynthesis, Antigens, Ly genetics, Atherosclerosis prevention & control, Chemokine CCL2 deficiency, Hypercholesterolemia genetics, Monocytes metabolism, Monocytes pathology, Receptors, CCR5 deficiency, Receptors, Chemokine deficiency
Abstract

Background: Monocytes are critical mediators of atherogenesis. Deletion of individual chemokines or chemokine receptors leads to significant but only partial inhibition of lesion development, whereas deficiency in other signals such as CXCL16 or CCR1 accelerates atherosclerosis. Evidence that particular chemokine pathways may cooperate to promote monocyte accumulation into inflamed tissues, particularly atherosclerotic arteries, is still lacking., Methods and Results: Here, we show that chemokine-mediated signals critically determine the frequency of monocytes in the blood and bone marrow under both noninflammatory and atherosclerotic conditions. Particularly, CCL2-, CX3CR1-, and CCR5-dependent signals differentially alter CD11b(+) Ly6G(-) 7/4(hi) (also known as Ly6C(hi)) and CD11b(+) Ly6G(-) 7/4(lo) (Ly6C(lo)) monocytosis. Combined inhibition of CCL2, CX3CR1, and CCR5 in hypercholesterolemic, atherosclerosis-susceptible apolipoprotein E-deficient mice leads to abrogation of bone marrow monocytosis and to additive reduction in circulating monocytes despite persistent hypercholesterolemia. These effects are associated with a marked and additive 90% reduction in atherosclerosis. Interestingly, lesion size highly correlates with the number of circulating monocytes, particularly the CD11b(+) Ly6G(-) 7/4(lo) subset., Conclusions: CCL2, CX3CR1, and CCR5 play independent and additive roles in atherogenesis. Signals mediated through these pathways critically determine the frequency of circulating monocyte subsets and thereby account for almost all macrophage accumulation into atherosclerotic arteries.

Published
2008
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