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14 results on '"Huan, Tianxiao"'

4. Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease

Author

Agha, Golareh, Mendelson, Michael M, Ward-Caviness, Cavin K, Joehanes, Roby, Huan, TianXiao, Gondalia, Rahul, Salfati, Elias, Brody, Jennifer A, Fiorito, Giovanni, Bressler, Jan, Chen, Brian H, Ligthart, Symen, Guarrera, Simonetta, Colicino, Elena, Just, Allan C, Wahl, Simone, Gieger, Christian, Vandiver, Amy R, Tanaka, Toshiko, Hernandez, Dena G, Pilling, Luke C, Singleton, Andrew B, Sacerdote, Carlotta, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Li, Yun, Zhang, Guosheng, Stewart, James D, Floyd, James S, Wiggins, Kerri L, Rotter, Jerome I, Multhaup, Michael, Bakulski, Kelly, Horvath, Steven, Tsao, Philip S, Absher, Devin M, Vokonas, Pantel, Hirschhorn, Joel, Fallin, M Daniele, Liu, Chunyu, Bandinelli, Stefania, Boerwinkle, Eric, Dehghan, Abbas, Schwartz, Joel D, Psaty, Bruce M, Feinberg, Andrew P, Hou, Lifang, Ferrucci, Luigi, Sotoodehnia, Nona, Matullo, Giuseppe, Peters, Annette, Fornage, Myriam, Assimes, Themistocles L, Whitsel, Eric A, Levy, Daniel, and Baccarelli, Andrea A

Subjects
Human Genome, Heart Disease, Clinical Research, Prevention, Heart Disease - Coronary Heart Disease, Atherosclerosis, Cardiovascular, Genetics, Adult, Aged, Cohort Studies, Coronary Disease, CpG Islands, DNA Methylation, Europe, Female, Genome-Wide Association Study, Humans, Incidence, Leukocytes, Male, Middle Aged, Myocardial Infarction, Population Groups, Prognosis, Prospective Studies, Risk, United States, coronary artery disease, coronary heart disease, epigenetics, genomics, gene expression regulation, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundDNA methylation is implicated in coronary heart disease (CHD), but current evidence is based on small, cross-sectional studies. We examined blood DNA methylation in relation to incident CHD across multiple prospective cohorts.MethodsNine population-based cohorts from the United States and Europe profiled epigenome-wide blood leukocyte DNA methylation using the Illumina Infinium 450k microarray, and prospectively ascertained CHD events including coronary insufficiency/unstable angina, recognized myocardial infarction, coronary revascularization, and coronary death. Cohorts conducted race-specific analyses adjusted for age, sex, smoking, education, body mass index, blood cell type proportions, and technical variables. We conducted fixed-effect meta-analyses across cohorts.ResultsAmong 11 461 individuals (mean age 64 years, 67% women, 35% African American) free of CHD at baseline, 1895 developed CHD during a mean follow-up of 11.2 years. Methylation levels at 52 CpG (cytosine-phosphate-guanine) sites were associated with incident CHD or myocardial infarction (false discovery rate

Published
2019

10. Abstract P097: Soluble TNF Receptor II Levels are Associated With Leukocyte DNA Methylation in the Major Histocompatibility Complex Region in the Framingham Heart Study

Author

Mendelson, Michael M, primary, Joehanes, Roby, additional, Liu, Chunyu, additional, Huan, Tianxiao, additional, Yao, Chen, additional, Murabito, Joanne M, additional, Dupuis, Josee, additional, Levy, Daniel, additional, Benjamin, Emelia J, additional, and Lin, Honghuang, additional

Published
2017
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11. Abstract 32: Novel Genetic Loci for Blood Pressure Regulation Identified by the Analysis of DNA Methylation

Author

Richard, Melissa A, primary, Huan, Tianxiao, additional, Ligthart, Symen, additional, Dehghan, Abbas, additional, Marioni, Riccardo E, additional, Brody, Jennifer A, additional, Sotoodehnia, Nona, additional, Jhun, Min A, additional, Kardia, Sharon L, additional, Smith, Jennifer A, additional, Irvin, M R, additional, Arnett, Donna K, additional, Aslibekyan, Stella, additional, Shen, J C, additional, Baccarelli, Andrea, additional, Just, Allan C, additional, Tsai, Pei-Chien, additional, Bell, Jordana T, additional, Spector, Tim D, additional, Guo, Xiuqing, additional, Rotter, Jerome A, additional, Palmas, Walter, additional, Liu, Yongmei, additional, Levy, Daniel, additional, and Fornage, Myriam, additional

Published
2016
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13. Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes

Author

Yao, Chen, primary, Chen, Brian H., additional, Joehanes, Roby, additional, Otlu, Burcak, additional, Zhang, Xiaoling, additional, Liu, Chunyu, additional, Huan, Tianxiao, additional, Tastan, Oznur, additional, Cupples, L. Adrienne, additional, Meigs, James B., additional, Fox, Caroline S., additional, Freedman, Jane E., additional, Courchesne, Paul, additional, O’Donnell, Christopher J., additional, Munson, Peter J., additional, Keles, Sunduz, additional, and Levy, Daniel, additional

Published
2015
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14. Abstract 18874: A microRNA Signature of Tobacco Exposure

Author

Willinger, Christine, primary, Rong, Jian, additional, Huan, Tianxiao, additional, Tanriverdi, Kahraman, additional, Courchesne, Paul, additional, Dupuis, Josée, additional, O’Connor, George, additional, Freedman, Jane, additional, Larson, Martin G, additional, and Levy, Daniel, additional

Published
2014
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