1. Wine drinking and risks of cardiovascular complications after recent acute myocardial infarction
- Author
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Francois Paillard, François Boucher, Michel de Lorgeril, Jean-Louis Martin, Joël de Leiris, Patricia Salen, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut des Matériaux Jean Rouxel (IMN), Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Ecole Polytechnique de l'Université de Nantes (EPUN), and Université de Nantes (UN)-Université de Nantes (UN)
- Subjects
Male ,Myocardial Infarction ,Alcohol ,Wine ,030204 cardiovascular system & hematology ,chemistry.chemical_compound ,0302 clinical medicine ,MESH: Risk Factors ,Recurrence ,Risk Factors ,030212 general & internal medicine ,Myocardial infarction ,Survivors ,Total energy ,MESH: Survivors ,MESH: Middle Aged ,MESH: Follow-Up Studies ,Middle Aged ,Prognosis ,3. Good health ,MESH: Myocardial Infarction ,MESH: Dietary Fats ,Cardiovascular Diseases ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,MESH: Ethanol ,MESH: Prognosis ,03 medical and health sciences ,Drug treatment ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Risk factor ,MESH: Humans ,Ethanol ,business.industry ,MESH: Cardiovascular Diseases ,medicine.disease ,Dietary Fats ,Confidence interval ,MESH: Wine ,MESH: Male ,Surgery ,MESH: Recurrence ,chemistry ,Ethanol intake ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Follow-Up Studies - Abstract
Background— Scientific data on the clinical impact of moderate alcohol consumption after a recent acute myocardial infarction (AMI) are limited, and the specific effect of wine ethanol has not been studied. Methods and Results— In survivors of a recent AMI, we analyzed the association between ethanol intake and the risk of recurrence. The patients were classified according to the amount of ethanol that they consumed regularly during follow-up. Major prognostic factors, including the severity of the prior AMI and drug treatment, were recorded and included in the analyses. Only patients with at least 2 reliable assessments of drinking (and dietary) habits were included (n=437). The average ethanol intake was 7.6% of the total energy intake, wherein wine ethanol represented 92% of the total. Among these patients, 104 cardiovascular complications occurred during a mean follow-up period of 4 years. In comparison with abstainers, the adjusted risk of complications was reduced by 59% (95% confidence interval: 17 to 80) in patients whose average ethanol intake was 7.7% of the total energy intake (about 2 drinks/day), and by 52% (95% confidence interval: 4 to 76) in those whose average ethanol intake was of 16% of energy (about 4 drinks/day). Conclusion— Whereas moderate wine drinking was associated with a significant reduction in the risk of complications in this homogenous population of coronary heart disease patients, further studies are required to confirm the data, define the clinical and biological profile of the patients who would most benefit from wine drinking after recent AMI, and examine whether the relations found are due to ethanol or other wine ingredients.
- Published
- 2002