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1. Subclinical Thyroid Dysfunction and the Risk of Heart Failure Events

Author

Gencer, Baris, Collet, Tinh-Hai, Virgini, Vanessa, Bauer, Douglas C, Gussekloo, Jacobijn, Cappola, Anne R, Nanchen, David, Elzen, Wendy PJ den, Balmer, Philippe, Luben, Robert N, Iacoviello, Massimo, Triggiani, Vincenzo, Cornuz, Jacques, Newman, Anne B, Khaw, Kay-Tee, Jukema, J Wouter, Westendorp, Rudi GJ, Vittinghoff, Eric, Aujesky, Drahomir, and Rodondi, Nicolas

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Clinical Research, Heart Disease, Cardiovascular, Metabolic and endocrine, Adult, Aged, Aged, 80 and over, Comorbidity, Female, Follow-Up Studies, Heart Failure, Humans, Hypothyroidism, Male, Middle Aged, Prospective Studies, Risk, Risk Factors, Sensitivity and Specificity, Thyrotropin, Thyroxine, cohort studies, epidemiology, heart failure, meta-analysis, thyroid, Thyroid Studies Collaboration, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences, Sports science and exercise
Abstract

BackgroundAmerican College of Cardiology/American Heart Association guidelines for the diagnosis and management of heart failure recommend investigating exacerbating conditions such as thyroid dysfunction, but without specifying the impact of different thyroid-stimulation hormone (TSH) levels. Limited prospective data exist on the association between subclinical thyroid dysfunction and heart failure events.Methods and resultsWe performed a pooled analysis of individual participant data using all available prospective cohorts with thyroid function tests and subsequent follow-up of heart failure events. Individual data on 25 390 participants with 216 248 person-years of follow-up were supplied from 6 prospective cohorts in the United States and Europe. Euthyroidism was defined as TSH of 0.45 to 4.49 mIU/L, subclinical hypothyroidism as TSH of 4.5 to 19.9 mIU/L, and subclinical hyperthyroidism as TSH

Published
2012

6. Abstract P211: A Method to Impute Life-course Trajectories of Cardiovascular Risk Factors from Pooled Cohorts Data

Author

Zhang, Yiyi, primary, Vittinghoff, Eric, additional, Pletcher, Mark J, additional, Allen, Norrina B, additional, Zeki Al Hazzouri, Adina, additional, Yaffe, Kristine, additional, Balte, Pallavi B, additional, Alonso, Alvaro, additional, Newman, Anne B, additional, Ives, Diane G, additional, Rana, Jamal S, additional, Lloyd-Jones, Donald, additional, Vasan, Ramachandran S, additional, Oelsner, Elizabeth C, additional, and Moran, Andrew E, additional

Published
2018
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7. Abstract P015: A Novel Healthy Blood Pressure Phenotype is Associated With Better Cardiovascular Health Benefits and Neuropsychological Performance in the Long Life Family Study

Author

Marron, Megan M, primary, Boudreau, Robert M, additional, Christensen, Kaare, additional, Cosentino, Stephanie, additional, Feitosa, Mary, additional, Minster, Ryan L, additional, Schupf, Nicol, additional, Sebastiani, Paola, additional, Ukraintseva, Svetlana, additional, Wojczynski, Mary K, additional, and Newman, Anne B, additional

Published
2017
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8. Abstract 13423: Sleep Disruption is Associated With Incident Atrial Fibrillation Independent of Obstructive Sleep Apnea

Author

Christensen, Matthew A, primary, Dixit, Shalini, additional, Whitman, Isaac R, additional, Nah, Gregory, additional, Dewland, Thomas A, additional, Vittinghoff, Eric, additional, Mukamal, Kenneth J, additional, Redline, Susan, additional, Robbins, John A, additional, Newman, Anne B, additional, Patel, Sanjay R, additional, Magnani, Jared W, additional, Psaty, Bruce M, additional, Heckbert, Susan R, additional, Olgin, Jeffrey E, additional, Pletcher, Mark J, additional, and Marcus, Gregory M, additional

Published
2016
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9. Abstract 13444: Decreased REM Sleep is Associated With Higher Risk of Incident Atrial Fibrillation

Author

Christensen, Matthew A, primary, Dixit, Shalini, additional, Vittinghoff, Eric, additional, Mukamal, Kenneth J, additional, Redline, Susan, additional, Robbins, John A, additional, Newman, Anne B, additional, Patel, Sanjay R, additional, Magnani, Jared W, additional, Psaty, Bruce M, additional, Heckbert, Susan R, additional, and Marcus, Gregory M, additional

Published
2016
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11. Abstract 19547: FOXO3 Genotype Strongly Impacts Coronary Heart Disease Mortality in Three Populations

Author

Willcox, Bradley J, primary, Morris, Brian J, additional, Tranah, Gregory J, additional, Chen, Randi, additional, Masaki, Kamal H, additional, He, Qimei, additional, Willcox, D. Craig, additional, Allsopp, Richard, additional, Moisyadi, Stefan, additional, Poon, Leonard W, additional, Rodriguez, Beatriz, additional, Newman, Anne B, additional, Harris, Tamara B, additional, Cummings, Steven R, additional, Liu, Yongmei, additional, Parimi, Neeta, additional, Evans, Daniel S, additional, and Donlon, Timothy A, additional

Published
2015
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12. Abstract 04: Incident Heart Failure and Longitudinal Cognitive Trajectories in the Cardiovascular Health Study

Author

Schank, Christa, primary, Blades, Natalie J, additional, Chaudhry, Sarwat I, additional, Dodson, John A, additional, Longstreth, W T, additional, Heckbert, Susan R, additional, Psaty, Bruce M, additional, Arnold, Alice M, additional, Dublin, Sascha, additional, Sitlani, Colleen M, additional, Gardin, Julius M, additional, Thielke, Stephen M, additional, Nanna, Michael, additional, Gottesman, Rebecca F, additional, Newman, Anne B, additional, and Thacker, Evan L, additional

Published
2015
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13. Abstract 20440: Cardiovascular Events in a Physical Activity Intervention as Compared to a Successful Aging Intervention: The LIFE Study Randomized Trial

Author

Newman, Anne B, primary, Dodson, John A, additional, Church, Timothy, additional, Bonds, Denise, additional, Buford, Thomas, additional, Fielding, Roger, additional, Kritchevsky, Stephen, additional, Beavers, Daniel P, additional, Pahor, Marco, additional, Stafford, Randall S, additional, Szady, Anita D, additional, and McDermott, Mary M, additional

Published
2014
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15. Associations of Total and High-Molecular-Weight Adiponectin With All-Cause and Cardiovascular Mortality in Older Persons

Author

Kizer, Jorge R., primary, Benkeser, David, additional, Arnold, Alice M., additional, Mukamal, Kenneth J., additional, Ix, Joachim H., additional, Zieman, Susan J., additional, Siscovick, David S., additional, Tracy, Russell P., additional, Mantzoros, Christos S., additional, deFilippi, Christopher R., additional, Newman, Anne B., additional, and Djousse, Luc, additional

Published
2012
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16. Abstract 056: Associations of Total and High-Molecular-Weight Adiponectin with All-Cause and Cardiovascular Mortality in Older Persons: The Cardiovascular Health Study (CHS)

Author

Kizer, Jorge R, primary, Benkeser, David, additional, Arnold, Alice M, additional, Mukamal, Kenneth J, additional, Ix, Joachim H, additional, Zieman, Susan J, additional, Siscovick, David S, additional, Tracy, Russell P, additional, Mantzoros, Christos S, additional, Newman, Anne B, additional, and Djousse, Luc, additional

Published
2012
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19. Abstract 5880: Serum Resistin Concentrations and Risk of New Onset Heart Failure in the Elderly

Author

Georgiopoulou, Vasiliki V, primary, Kalogeropoulos, Andreas P, additional, de Rekeneire, Nathalie, additional, Rodondi, Nicolas, additional, Smith, Andrew L, additional, Hoffmann, Udo, additional, Kanaya, Alka, additional, Newman, Anne B, additional, Kritchevsky, Stephen B, additional, Vasan, Ramachandran S, additional, Wilson, Peter W, additional, Harris, Tamara B, additional, and Butler, Javed, additional

Published
2008
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20. Abstract 2385: Epidemiology of Incident Heart Failure in a Contemporary Elderly Population: The Health, Aging, and Body Composition (Health ABC) Study

Author

Kalogeropoulos, Andreas P, primary, Georgiopoulou, Vasiliki V, additional, Kritchevsky, Stephen, additional, Psaty, Bruce, additional, Rodondi, Nicolas, additional, Smith, Nicholas, additional, Bauer, Douglas C, additional, Bibbins-Domingo, Kirsten, additional, Satterfield, Suzanne, additional, Smith, Andrew L, additional, Newman, Anne B, additional, Vasan, Ramachandran, additional, Harris, Tamara B, additional, Wilson, Peter W, additional, and Butler, Javed, additional

Published
2008
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23. Inflammatory Markers and Onset of Cardiovascular Events

Author

Cesari, Matteo, primary, Penninx, Brenda W.J.H., additional, Newman, Anne B., additional, Kritchevsky, Stephen B., additional, Nicklas, Barbara J., additional, Sutton-Tyrrell, Kim, additional, Rubin, Susan M., additional, Ding, Jingzhong, additional, Simonsick, Eleanor M., additional, Harris, Tamara B., additional, and Pahor, Marco, additional

Published
2003
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24. Prevention Conference VI: Diabetes and Cardiovascular Disease

Author

Redberg, Rita F., primary, Greenland, Philip, additional, Fuster, Valentin, additional, Pyörälä, Kalevi, additional, Blair, Steven N., additional, Folsom, Aaron R., additional, Newman, Anne B., additional, O’Leary, Daniel H., additional, Orchard, Trevor J., additional, Psaty, Bruce, additional, Schwartz, J. Sanford, additional, Starke, Rodman, additional, and Wilson, Peter W.F., additional

Published
2002
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33. Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.

Author

O'Donnell CJ, Kavousi M, Smith AV, Kardia SL, Feitosa MF, Hwang SJ, Sun YV, Province MA, Aspelund T, Dehghan A, Hoffmann U, Bielak LF, Zhang Q, Eiriksdottir G, van Duijn CM, Fox CS, de Andrade M, Kraja AT, Sigurdsson S, Elias-Smale SE, Murabito JM, Launer LJ, van der Lugt A, Kathiresan S, Krestin GP, Herrington DM, Howard TD, Liu Y, Post W, Mitchell BD, O'Connell JR, Shen H, Shuldiner AR, Altshuler D, Elosua R, Salomaa V, Schwartz SM, Siscovick DS, Voight BF, Bis JC, Glazer NL, Psaty BM, Boerwinkle E, Heiss G, Blankenberg S, Zeller T, Wild PS, Schnabel RB, Schillert A, Ziegler A, Münzel TF, White CC, Rotter JI, Nalls M, Oudkerk M, Johnson AD, Newman AB, Uitterlinden AG, Massaro JM, Cunningham J, Harris TB, Hofman A, Peyser PA, Borecki IB, Cupples LA, Gudnason V, and Witteman JC

Subjects
Adult, Aged, Aged, 80 and over, Calcinosis diagnostic imaging, Calcinosis epidemiology, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease epidemiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction diagnostic imaging, Myocardial Infarction epidemiology, Polymorphism, Single Nucleotide genetics, Radiography, Risk Factors, Calcinosis genetics, Coronary Artery Disease genetics, Genome-Wide Association Study, Myocardial Infarction genetics
Abstract

Background: Coronary artery calcification (CAC) detected by computed tomography is a noninvasive measure of coronary atherosclerosis, which underlies most cases of myocardial infarction (MI). We sought to identify common genetic variants associated with CAC and further investigate their associations with MI., Methods and Results: Computed tomography was used to assess quantity of CAC. A meta-analysis of genome-wide association studies for CAC was performed in 9961 men and women from 5 independent community-based cohorts, with replication in 3 additional independent cohorts (n=6032). We examined the top single-nucleotide polymorphisms (SNPs) associated with CAC quantity for association with MI in multiple large genome-wide association studies of MI. Genome-wide significant associations with CAC for SNPs on chromosome 9p21 near CDKN2A and CDKN2B (top SNP: rs1333049; P=7.58×10(-19)) and 6p24 (top SNP: rs9349379, within the PHACTR1 gene; P=2.65×10(-11)) replicated for CAC and for MI. Additionally, there is evidence for concordance of SNP associations with both CAC and MI at a number of other loci, including 3q22 (MRAS gene), 13q34 (COL4A1/COL4A2 genes), and 1p13 (SORT1 gene)., Conclusions: SNPs in the 9p21 and PHACTR1 gene loci were strongly associated with CAC and MI, and there are suggestive associations with both CAC and MI of SNPs in additional loci. Multiple genetic loci are associated with development of both underlying coronary atherosclerosis and clinical events.

Published
2011
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34. Atherosclerotic Peripheral Vascular Disease Symposium II: nomenclature for vascular diseases.

Author

Hiatt WR, Goldstone J, Smith SC Jr, McDermott M, Moneta G, Oka R, Newman AB, and Pearce WH

Subjects
American Heart Association, Atherosclerosis diagnosis, Humans, Peripheral Vascular Diseases diagnosis, United States, Vascular Diseases classification, Vascular Diseases diagnosis, Atherosclerosis classification, Peripheral Vascular Diseases classification, Terminology as Topic
Published
2008
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35. Mortality and cardiovascular risk across the ankle-arm index spectrum: results from the Cardiovascular Health Study.

Author

O'Hare AM, Katz R, Shlipak MG, Cushman M, and Newman AB

Subjects
Aged, Ankle blood supply, Arm blood supply, Blood Pressure, Body Mass Index, Cholesterol, LDL blood, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Risk Factors, Smoking mortality, Peripheral Vascular Diseases diagnosis, Peripheral Vascular Diseases mortality
Abstract

Background: A low ankle-arm index (AAI) is a strong predictor of mortality and cardiovascular events. A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population., Methods and Results: We examined total and cardiovascular mortality and cardiovascular events across the AAI spectrum among 5748 participants in the Cardiovascular Health Study (CHS). The mean age of the sample population was 73+/-6 years, and the sample included 3289 women (57%) and 883 blacks (15%). The median duration of follow-up was 11.1 (0.1 to 12) years for mortality and 9.6 (0.1 to 12.1) years for cardiovascular events. There were 2311 deaths (953 of which were cardiovascular) and 1491 cardiovascular events during follow-up. After adjustment for potential confounders, AAI measurements < or =0.60 (hazard ratio [HR] 1.82, 95% CI 1.42 to 2.32), 0.61 to 0.7 (HR 2.08, 95% CI 1.61 to 2.69), 0.71 to 0.8 (HR 1.80, 95% CI 1.44 to 2.26), 0.81 to 0.9 (HR 1.73 95% CI 1.43 to 2.11), 0.91 to 1.0 (HR 1.40, 95% CI 1.20 to 1.63), and >1.40 (HR 1.57, 95% CI 1.07 to 2.31) were associated with higher mortality risk from all causes compared with the referent group (AAI 1.11 to 1.20). The pattern was similar for cardiovascular mortality. For cardiovascular events, risk was higher at all AAI levels <1 but not for AAI levels >1.4 (HR 1.00, 95% CI 0.57 to 1.74). The association of a high AAI with mortality was stronger in men than in women and in younger than in older cohort members., Conclusions: In a cohort of community-dwelling elders, mortality risk was higher than the referent category of 1.11 to 1.2 among participants with AAI values above the traditional cutpoint of 0.9 (ie, 0.91 to 1.0 and >1.4), and the specific association of AAI with mortality varied by age and gender.

Published
2006
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