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1. Abstract MP09: Untargeted 1 H Nmr Metabolomics Metabolomic Analysis Reveals Pathways Of Protection Between Mediterranean-style Diet And Incident Cardiovascular Disease In The Multi-ethnic Study Of Atherosclerosis.

Author

Wood, Alexis C, primary, Saylor, Georgina, additional, Tzoulaki, Ioanna, additional, Greenland, Philip, additional, Tracy, Russell P, additional, Post, Wendy S, additional, Lindon, John, additional, Wassel, Christina L, additional, Phan, Mimi, additional, Momin, Shabnam, additional, Ebbels, Tim, additional, Boulange, Claire, additional, Graça, Goncalo, additional, Karaman, Ibrahim, additional, Gadghil, Meghana, additional, Chekmeneva, Elena, additional, Kaluarachchi, Manuja, additional, Elliott, Paul, additional, and Herrington, David M, additional

Published
2021
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7. Abstract P369: Hepatocyte Growth Factor is Positively Associated With Progression of Atherosclerosis: the Multi-Ethnic Study of Atherosclerosis

Author

Bell, Elizabeth J, primary, Decker, Paul A, additional, Stein, James H, additional, Tsai, Michael Y, additional, Pankow, James S, additional, Hanson, Naomi Q, additional, Wassel, Christina L, additional, Larson, Nicholas B, additional, Cohoon, Kevin, additional, Budoff, Matthew, additional, Polak, Joseph F, additional, and Bielinski, Suzette J, additional

Published
2017
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8. Abstract P363: Ectopic Adiposity is Associated With Abdominal Aorto-Illiac but Not Coronary Artery Calcification Independent of Total Body Adiposity in African Ancestry Men

Author

Kuipers, Allison L, primary, Zmuda, Joseph M, additional, Carr, J Jeffrey, additional, Terry, James G, additional, Nair, Sangeeta, additional, Cvejkus, Ryan, additional, Bunker, Clareann H, additional, Patrick, Alan L, additional, Wassel, Christina L, additional, and Miljkovic, Iva, additional

Published
2017
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9. Abstract P103: Genetic Analysis of Admixed US Populations Identifies Associations with Mean Corpuscular Volume

Author

Hodonsky, Chani J, primary, Nishimura, Katherine K, additional, Tao, Ran, additional, Buyske, Steve, additional, Fornage, Myriam, additional, Hindorff, Lucia A, additional, Kocarnik, Jonathan, additional, Li, Yun, additional, Lin, Danyu, additional, Loos, Ruth J, additional, Tang, Weihong, additional, Thyagarajan, Bharat, additional, Wassel, Christina L, additional, Reiner, Alex P, additional, North, Kari E, additional, Kooperberg, Charles L, additional, and Avery, Christy L, additional

Published
2017
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10. Abstract P266: Prevalence and Age-related Trends of Subclinical Cardiovascular Disease Burden in Adult Afro-Caribbean Men From Tobago

Author

Kuipers, Allison L, primary, Miljkovic, Iva, additional, Carr, J J, additional, Terry, James G, additional, Nair, Sangeeta, additional, Ge, Yaorong, additional, Cvejkus, Ryan, additional, Bunker, Clareann H, additional, Patrick, Alan L, additional, Wassel, Christina L, additional, and Zmuda, Joseph M, additional

Published
2016
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11. Abstract 02: American Heart Association (AHA)’s Life’s Simple 7 and Risk of Lower Extremity Peripheral Artery Disease (PAD): The Multi-Ethnic Study of Atherosclerosis (MESA)

Author

Wassel, Christina L, primary, Rasmussen-Torvik, Laura, additional, Frazier-Wood, Alexis, additional, Allison, Matthew A, additional, McDermott, Mary M, additional, Folsom, Aaron R, additional, Lloyd-Jones, Donald M, additional, Allen, Norrina B, additional, Burke, Gregory L, additional, Szklo, Moyses, additional, Criqui, Michael H, additional, and Cushman, Mary, additional

Published
2016
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15. Abstract 16346: Soluble P-Selectin Predicts Lower Extremity Peripheral Artery Disease Incidence and Change in the Ankle Brachial Index: The Multi-Ethnic Study of Atherosclerosis (MESA)

Author

Wassel, Christina L, primary, Berardi, Cecilia, additional, Pankow, James S, additional, Larson, Nicholas B, additional, Decker, Paul A, additional, Hanson, Naomi Q, additional, Tsai, Michael Y, additional, Criqui, Michael H, additional, Allison, Matthew A, additional, and Bielinski, Suzette J, additional

Published
2014
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16. Abstract P252: Generalization and Fine Mapping of PR Interval Loci in Hispanics: The Population Architecture Using Genomics and Epidemiology (PAGE) Study

Author

Seyerle, Amanda A, primary, Wassel, Christina, additional, Carty, Cara L, additional, Fornage, Myriam, additional, Bielinski, Suzette J, additional, Buyske, Steve, additional, Carnethon, Mercedes R, additional, Crawford, Dana C, additional, Duggan, David J, additional, Gong, Jian, additional, Heckbert, Susan R, additional, Hindorff, Lucia A, additional, Jeff, Janina M, additional, Lloyd-Jones, Donald M, additional, Okin, Peter M, additional, Perez, Marco V, additional, Psaty, Bruce M, additional, Rotter, Jerome I, additional, Shah, Sanjiv J, additional, Shohet, Ralph V, additional, Soliman, Elsayed Z, additional, Sotoodehnia, Nona, additional, Wu, Chunyuan, additional, Kooperberg, Charles, additional, and Avery, Christy L, additional

Published
2014
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18. Abstract P256: Association of Genetic Variants on the Metabochip With Urine Albumin-Creatinine Ratio in African Americans: The Population Architecture using Genomics and Epidemiology (PAGE) Study

Author

Wassel, Christina L, primary, Wong, Quenna, additional, Li, Man, additional, Goodloe, Robert J, additional, Graff, Misa, additional, Tao, Ran, additional, Shao, Yaming, additional, Crawford, Dana C, additional, Buyske, Steve, additional, Buzkova, Petra, additional, Jenny, Nancy S, additional, Bielinski, Suzette J, additional, Pankow, James S, additional, Rich, Stephen S, additional, Chen, Ida, additional, Taylor, Kent D, additional, Mychaleckyj, Josyf, additional, Wise, Anastasia, additional, Ix, Joachim H, additional, Rifkin, Dena, additional, Junkins, Heather, additional, Fornage, Myriam, additional, Kao, Linda, additional, North, Kari E, additional, and Franceschini, Nora, additional

Published
2014
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25. Abstract P229: Genetic Risk Scores are Associated with Chronic Venous Disease Prevalence and Severity in a Multi-Ethnic Cohort: The San Diego Population Study (SDPS)

Author

Wassel, Christina L, primary, Rasmussen-Torvik, Laura J, additional, Callas, Peter W, additional, Denenberg, Julie O, additional, Durda, Peter, additional, Reiner, Alexander P, additional, Smith, Nicholas L, additional, Allison, Matthew A, additional, Criqui, Michael H, additional, and Cushman, Mary, additional

Published
2012
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29. MicroRNAs Implicated in Angiogenesis Are Upregulated in Lower Extremity Peripheral Artery Disease (PAD): the San Diego Population Study (SDPS).

Author

Wassel, Christina, Freedman, Jane E., Tanriverdi, Kahraman, Durda, Peter, Tracy, Russell P., Allison, Matthew A., Ix, Joachim H., Denenberg, Julie O., and Criqui, Michael H.

Abstract

Introduction: Lower extremity PAD affects approximately 9 million people in the US. However, the genetic factors underlying PAD remain elusive. MicroRNAs are short non-coding RNA segments that regulate gene expression post-transcriptionally. MicroRNAs are hypothesized to be involved in angiogenesis, inflammation, and immune processes central to atherosclerotic process, are modifiable, and thus have potential as therapeutic targets. No previous studies have assessed the role of microRNAs in PAD in a population-based sample. Methods: The SDPS is a prospective population-based cohort of non-Hispanic White, African-American, Hispanic and Asian men and women designed to study PAD and venous disease. A sex- and age-matched nested sample of 24 PAD cases and 24 controls were chosen from 1103 participants who attended the 2007-11 exam. PAD was defined as ankle brachial index (ABI)<0.90, while the ABI range for controls was 1.1-1.3. Thirty-five microRNAs hypothesized to be of importance in development of atherosclerosis were measured in plasma using a high throughput RT qPCR method on the BioMark microfluidic System. MicroRNA expression levels (Cq values) were compared between PAD cases and controls using linear regression and least squares means, with adjustment for age and sex to remove residual confounding. Results: Overall mean±SD age was 79±7, with mean ABI among the PAD cases of 0.60±0.12 and among controls was 1.17±0.06.Six microRNAs, miR-181b, -195, -22, -27b, -424, and -503, were significantly upregulated in PAD cases vs. controls (Figure), all p<0.05. Existing evidence indicates that miR-195,-27b, -424, and -503 are involved in angiogenesis, and miR-503 is upregulated in ischemic leg muscle of patients with diabetes. Conclusions: Individuals with PAD have significantly higher expression of miRNAs linked to angiogenesis. Additional research is needed in larger studies to further assess associations with clinical and subclinical PAD, as well as the viability of these miRNAs as therapeutic targets for PAD. [ABSTRACT FROM AUTHOR]

Published
2017
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34. Association of Genetic Variants on the Metabochip With Urine Albumin-Creatinine Ratio in African Americans: The Population Architecture using Genomics and Epidemiology (PAGE) Study.

Author

Wassel, Christina L., Quenna Wong, Man Li, Goodloe, Robert J., Graff, Misa, Ran Tao, Yaming Shao, Crawford, Dana C., Buyske, Steve, Buzkova, Petra, Jenny, Nancy S., Bielinski, Suzette J., Pankow, James S., Rich, Stephen S., Chen, Ida, Taylor, Kent D., Mychaleckyj, Josyf, Wise, Anastasia, Ix, Joachim H., and Rifkin, Dena

Subjects
*AFRICAN Americans, *BONE density, *SYSTEMIC lupus erythematosus, *GENOMICS, *WAIST circumference
Abstract

Several loci have been discovered and replicated for urine albumin-creatinine ratio (ACR), a measure of kidney function, in European populations; however, other ethnic populations such as African-Americans have been less studied for this trait. We examined the association of genetic variants on the Metabochip with natural log transformed ACR (ln(ACR)) in 4,629 African-Americans from the Population Architecture using Genomics and Epidemiology (PAGE) Study which includes participants from the Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Coronary Artery Risk Development in Young Adults (CARDIA), and Epidemiologic Architecture for Genes Linked to the Environment (EAGLE-BioVU) studies. We then replicated our findings in 1,533 African-American participants from the Multi-Ethnic Study of Atherosclerosis (MESA). Linear regression models were used to examine associations, assuming additive effects of the SNPs. Within each study, models were adjusted for age, field center (where applicable), and principal components of ancestry, and stratified by sex. Fixed effects inverse variance weighted meta-analysis was used to combine results from contributing studies. Array-wide statistical significance was concluded for SNP associations of p-value less than 2.8 x 10-7. Mean ln(ACR) ranged from 1.4 to 2.9 mg/g, average age ranged from 44 to 77 years, and percent female participants ranged from 59- 65% in the contributing studies. Four SNPs were significantly associated array-wide with ACR in the discovery sample: rs17399841 in GRHL2 (β=-0.67, MAF=0.01, p=2.7x10-9), rs153914 near SPATA9/RHOBTB3 (β=-0.59, MAF=0.01, p=1.0x10- 7), rs17439845 in LEF1 (β=-0.49, MAF=0.02, p=1.3x10-7), and rs11836243 near ZNF641/ANP32D (β=0.23, MAF=0.12, p=1.8x10-7). Of these four loci, only the association of rs17439845 with ACR replicated in MESA (β=-0.36, p=0.038), with a combined discovery-replication beta of -0.46 and p value of 1.8x10-8. Combined discovery-replication for rs17399841, rs153914, and rs11836243 no longer achieved array-wide significance (p-values 9.84x10-7, 1.98x10-5, and 1.32x10-4, respectively). LEF1 is a mediator in the Wnt signaling pathway, and has been previously implicated in systemic lupus erythematosus and osteoporosis, as well as previously associated with waist circumference, echocardiographic traits, bone mineral density, and blood count traits. Continuing studies in diverse populations are warranted to identify a set of loci important in contributing to the variation in ACR. [ABSTRACT FROM AUTHOR]

Published
2014

35. Generalization and Fine Mapping of PR Interval Loci in Hispanics: The Population Architecture Using Genomics and Epidemiology (PAGE) Study.

Author

Seyerle, Amanda A., Wassel, Christina, Carty, Cara L., Fornage, Myriam, Bielinski, Suzette J., Buyske, Steve, Carnethon, Mercedes R., Crawford, Dana C., Duggan, David J., Jian Gong, Heckbert, Susan R., Hindorff, Lucia A., Jeff, Janina M., Lloyd-Jones, Donald M., Okin, Peter M., Perez, Marco V., Psaty, Bruce M., Rotter, Jerome I., Shah, Sanjiv J., and Shohet, Ralph V.

Subjects
*HEART failure, *STROKE, *SYSTOLIC blood pressure, *ARRHYTHMIA, *BODY mass index, *GENOMICS, *ATRIAL fibrillation
Abstract

PR interval (PR) prolongation is a predictor of atrial fibrillation, a common cardiac arrhythmia, and is an established risk factor for pacemaker implantation, heart failure, stroke, and all-cause mortality. Previous genome-wide association studies in European (EU) and African (AA) descent populations have identified multiple loci associated with PR. However, it is unclear whether these loci are relevant in other racial groups, including Hispanic/Latinos (HL). Extending studies to include admixed populations such as HL also provides the potential to narrow regions associated with PR and identify population specific variants. Therefore, we evaluated 1,135 SNPs from four previously identified PR loci (SCN5A, SCN10A, CAV1-CAV2, and TBX5-TBX3), fine-mapped on the Illumina Metabochip for association with PR. Associations were examined using linear regression assuming an additive genetic model and adjusting for global ancestry and clinical covariates (age, sex, RR interval, body mass index, height, systolic blood pressure) in 11,800 HL participants from participating studies of the Population Architecture using Genomics and Epidemiology (PAGE) consortia. Three of the four loci (SCN5A, SCN10A, and CAV1-CAV2) generalized to HL populations (P<7.1E-4 based on the number of SNPs correlated at r²>0.2 with EU-identified index SNPs). At each of these loci, we identified SNPs with stronger evidence of association with PR than the EU-identified index SNP when examined in the HL population (SCN5A: rs7374540; SCN10A: rs6801957; CAV-CAV2: rs717957). Conditional analyses also identified two additional independent SNPs at each of the three generalized loci (SCN5A: rs3796387, rs9861242; SCN10A: rs10428132, rs7433723; CAV1-CAV2: rs3801995, rs3807994), representing potential secondary signals. Furthermore, linkage disequilibrium (LD) patterns in Hispanics enabled the narrowing of the regions flanking the EU-identified index SNPs. For example, at the CAV1-CAV2 locus, HL LD patterns indicated that seven SNPs were in LD with rs3807989, the EU-identified index SNP, compared to 17 SNPs that were in LD with rs3807989 when applying EU LD patterns, reducing the size of the region by 71 kilobases. Finally, we examined evidence for population specific signals outside of the specific regions identified in EU populations which were associated with PR in Hispanics by focusing on SNPs uncorrelated with the EU index signals. At all four loci, multiple SNPs had evidence of association independent of the signals examined based on EU results. In conclusion, the same genetic loci that influence PR in European descent populations are also important in Hispanic populations, although we detected evidence for population specific SNPs. These results emphasize the importance of examining genetic associations in diverse populations in order to narrow the genomic interval for future functional interrogation. [ABSTRACT FROM AUTHOR]

Published
2014

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