1. In Vivo Quantitative Tissue Characterization of Angiographically Normal Coronary Lesions and the Relation With Risk Factors A Study Using Integrated Backscatter Intravascular Ultrasound
- Author
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Takao Kawai, Ichijiro Murata, Kunihiko Tsuchiya, Kazuhiko Nishigaki, Hisayoshi Fujiwara, Masanori Kawasaki, Hiroshi Fujita, Shinya Minatoguchi, Keiji Sano, Yo ko Ito, Genzou Takemura, Haruko Yokoyama, Munenori Okubo, and Xiangrong Zhou
- Subjects
Pathology ,medicine.medical_specialty ,Intimal hyperplasia ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Coronary artery disease ,In vivo ,Fibrosis ,Diabetes mellitus ,Intravascular ultrasound ,Hyperlipidemia ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Coronary atherosclerosis - Abstract
Background Autopsy studies have shown atherosclerotic changes in angiographically normal coronary lesions (ANCL), and conventional intravascular ultrasound shows intimal thickening in these lesions, but cannot differentiate the lipid core. Accurate characterization of ANCL is essential to prevent progression to coronary artery disease. Methods and Results ANCL (n=120) were analyzed by integrated backscatter intravascular ultrasound (IB-IVUS) in 30 patients with stable angina pectoris. Of the 120 arterial segments analyzed by IB-IVUS, 78 (65%) showed lipid cores of 0.69±0.35 mm2 with fibrous caps of 200±100 μm thick, 44 (37%) had intimal hyperplasia with a thickness of 350±100 μm, and 65 (54%) showed fibrosis in the intimal wall without lipid core with a thickness of 450±150 μm. The diabetes mellitus (DM) group (n=14) had significantly (p
- Published
- 2005
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