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This is the second of the two-part paper series on the analysis and evaluation of the Fifth phase of Coupled Model Intercomparison Project (CMIP5) simulation of contemporary climate as well as IPCC, AR5 Representative Concentrations Pathways (RCP), 4.5 and 8.5 scenarios projections of the Greater Horn of Africa (GHA) Climate. In the first part (Otieno and Anyah in Clim Dyn, ) we focused on the historical simulations, whereas this second part primarily focuses on future projections based on the two scenarios. Six Earth System Models (ESMs) from CMIP5 archive have been used to characterize projected changes in seasonal and annual mean precipitation, temperature and the hydrological cycle by the middle of twenty-first century over the GHA region, based on IPCC, 5th Assessment Report (AR5) RCP4.5 and RCP8.5 scenarios. Nearly all the models outputs analyzed reproduce the correct mean annual cycle of precipitation, with some biases among the models in capturing the correct peak of precipitation cycle, more so, March-April-May (MAM) seasonal rainfall over the equatorial GHA region. However, there is significant variation among models in projected precipitation anomalies, with some models projecting an average increase as others project a decrease in precipitation during different seasons. The ensemble mean of the ESMs indicates that the GHA region has been experiencing a steady increase in both precipitation and temperature beginning in the early 1980s and 1970s respectively in both RCP4.5 and RCP8.5 scenarios. Going by the ensemble means, temperatures are projected to steadily increase uniformly in all the seasons at a rate of 0.3/0.5 °C/decade under RCP4.5/8.5 scenarios over northern GHA region leading to an approximate temperature increase of 2/3 °C by the middle of the century. On the other hand, temperatures will likely increase at a rate of 0.3/0.4 °C/decade under RCP4.5/8.5 scenarios in both equatorial and southern GHA region leading to an approximate temperature increase of 2/2.5 °C by the middle of twenty-first century. Nonetheless, projected precipitation increase varied across seasons and sub-regions. With the exception of the equatorial region, that is projected to experience precipitation increase during DJF season, most sub-regions are projected to experience precipitation increase within their peak seasons, with the highest rate of increase experienced during DJF and OND seasons over southern and equatorial GHA regions respectively. Notably, as precipitation increases, the deficit (E < P) between evaporation (E) and precipitation (P) increased over the years, with a negatively skewed distribution. This generally implies that there is a high likelihood of an increased deficit in local moisture supply. This remarkable change in the general hydrological cycle (i.e. deficit in local moisture) is projected to be also coincident with intensified westerly anomaly influx from the Congo basin into the region. However, better understanding of the detailed changes in hydrological cycle will require comprehensive water budget analyses that require daily or sub-daily variables, and was not a specific focus of the present study. [ABSTRACT FROM AUTHOR]