1. Antigen-Specific T Cells and Cytokines Detection as Useful Tool for Understanding Immunity against Zoonotic Infections.
- Author
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Agnone, Annalisa, Torina, Alessandra, Vesco, Gesualdo, Villari, Sara, Vitale, Fabrizio, Caracappa, Santo, La Manna, Marco Pio, Dieli, Francesco, and Sireci, Guido
- Subjects
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ANTIGENS , *T cells , *CYTOKINES , *IMMUNITY , *ZOONOSES , *IMMUNE response , *IMMUNOLOGICAL tolerance , *EUKARYOTIC cells - Abstract
Zoonoses include a broad range of diseases, that are becoming of great interest, due to the climate changing, that cause the adaptation of vectors to new niches and environments. Host immune responses play a crucial role in determining the outcome of infections, as documented by expansion of antigen-specific T cells during several zoonotic infections. Thus, understanding of the contribution of antigen-specific T-cell subsets in the host immune response is a powerful tool to evaluate the different immunological mechanisms involved in zoonotic infections and for the development of effective vaccines. In this paper we discuss the role of T cells in some eukaryotic and prokaryotic infectious models. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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