1. CARD9 balances Aspergillus fumigatus‐induced anti‐fungal immunity and allergic inflammation.
- Author
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Xu, Xia, Li, Fan, Huang, Ronghua, Wu, Siyuan, Huang, Zhiwen, and Duan, Jielin
- Subjects
IMMUNITY ,PULMONARY eosinophilia ,ASPERGILLUS ,IMMUNOGLOBULIN E ,ALVEOLAR macrophages ,T helper cells ,PULMONARY aspergillosis ,ANTIALLERGIC agents - Abstract
Keywords: Allergic inflammation; Alveolar macrophages; Aspergillus fumigatus; CARD9 EN Allergic inflammation Alveolar macrophages Aspergillus fumigatus CARD9 659 663 5 06/09/23 20230601 NES 230601 Key message CARD9 enhances pro-inflammatory immune response, but inhibits pulmonary type 2 immunity after I A. fumigatus i exposure. Moreover, we sorted out alveolar macrophages from WT and CARD9 deficient mice infected with/without I A. fumigatus i , and further confirmed that RelB activation only occurred in CARD9 deficient alveolar macrophages. Simultaneously, we found that the expression of CD80, CD86 and MHC-II were comparable between WT and CARD9 deficient mice with/without I A. fumigatus i exposure, hinting that CARD9 did not affect the antigen presentation capacity of alveolar macrophages. CARD9 balances Aspergillus fumigatus-induced anti-fungal immunity and allergic inflammation. [Extracted from the article]
- Published
- 2023
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