Search

Keywords: accidental use; adrenaline; adverse effect; anaphylaxis; auto-injector; digital injection; side effect EN accidental use adrenaline adverse effect anaphylaxis auto-injector digital injection side effect 955 958 4 09/05/23 20230901 NES 230901 DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. In 3/6 cases, the ADRs occurred following a single adrenaline injection: chest tightness and paresthesia of the extremities ( I n i = 1), hypertension ( I n i = 1), and induration at the injection site ( I n i = 1). A US survey conducted with poison control centres (PCCs) (1994-2007) found 15,190 accidental injections related to AAIs, of which 0.2% were severe.[5] In our study, no side effects were observed related to accidental digital injections and no patient received vasodilators. [Extracted from the article]

Background Poorly documented self-reported drug allergy (DAll) is a frequent problem in daily clinical practice and has a considerable impact on prescription choices. The diagnostic work-up of drug hypersensitivity (DHs) allows a better classification of the reactions and provides patients with more reliable information and recommendations for future treatments. Objective To assess the prevalence of self-reported adverse drug reactions (ADRs) and DAll in a paediatric population and to investigate children reporting suspected DAll in order to achieve a firm diagnosis. Design The first phase was based on a cross-sectional survey assessing the life occurrence of ADRs and self-reported DAll carried out at the outpatient clinic of a paediatric hospital. The second phase was based on the diagnostic work-up in children with parent-reported DAll, including detailed anamnesis and in vitro and in vivo investigations (skin and provocation tests). Participants One thousand four hundred and twenty-six parents responded to the initial survey. Sixty of the 67 patients with reported DAll were evaluated at the allergy clinic. Results The prevalences of self-reported ADRs and DAll were 10.2% and 6.0%, respectively. Most of the suspected allergic reactions were non-immediate cutaneous events attributable to β-lactam antibiotics and occurred in very young children. Thirty-nine of the 60 patients consulting for evaluation had a plausible clinical history and were recommended further investigation. DHs was diagnosed in three children only, based on positive responses in skin ( n=1) and oral provocation ( n=2) tests. Conclusion ADRs are frequently reported in children, and many children are classified as having a DAll. After complete evaluation, only a few of these reactions can be attributed to DHs and DAll. Most of the patients (94% in this study) could actually tolerate the initially suspected drug. [ABSTRACT FROM AUTHOR]

To estimate the prevalence of self-reported drug allergy in adults.Cross-sectional survey of a general adult population from Porto (all of whom were living with children involved in the International Study of Asthma and Allergies in Childhood–phase three), during the year 2002, using a self-administered questionnaire.The prevalence of self-reported drug allergy was 7.8% (181/2309): 4.5% to penicillins or otherβ-lactams, 1.9% to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) and 1.5% to other drugs. In the group‘allergic toβ-lactams’, the most frequently implicated drug was penicillin G or V (76.2%) followed by the association of amoxicillin and clavulanic acids (14.3%). In the group‘allergic to NSAIDs’, acetylsalicylic acid (18.2%) and ibuprofen (18.2%) were the most frequently identified drugs, followed by nimesulide and meloxicam. Identification of the exact name of the involved drug was possible in less than one-third of the patients, more often within the NSAID group (59.5%). Women were significantly more likely to claim a drug allergy than men (10.2% vs. 5.3%). The most common manifestations were cutaneous (63.5%), followed by cardiovascular symptoms (35.9%). Most of the reactions were immediate, occurring on the first day of treatment (78.5%). Only half of the patients were submitted to drug allergy investigations. The majority (86.8%) completely avoided the suspected culprit drug thereafter.The results showed that self-reported allergy to drugs is highly prevalent and poorly explored. Women seem to be more susceptible.β-lactams and NSAIDs are the most frequently concerned drugs. [ABSTRACT FROM AUTHOR]