1. What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 1. Epidemiology, risk factors and outcomes.
- Author
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Hatfield, S. J., Rogers, N. K., Lloyd‐Lavery, A., Grindlay, D., Barnett, R., and Thomas, K. S.
- Subjects
ECZEMA ,ATOPIC dermatitis ,EPIDEMIOLOGY ,BIRTH weight ,SOCIOECONOMIC factors ,DISEASE prevalence ,RISK factors of attention-deficit hyperactivity disorder - Abstract
This review summarizes key findings from nine systematic reviews on atopic eczema ( AE) published or first indexed in 2014. It focuses on epidemiology, disease processes and methodological issues. There is reasonable evidence to conclude that high birth weight (> 4000 g) is a risk factor for the development of AE. A lower socioeconomic position is associated with lower prevalence of AE. The effect of exposure to traffic-related air pollution in childhood on the development of AE is uncertain. CD14 polymorphisms do not appear to have an effect in AE. There may be a role for interleukin-18 in AE development. Patients with AE are at decreased risk of brain tumours, but at increased risk of developing attention deficit hyperactivity disorder. Evidence supports the view that normal-appearing skin in AE is in fact structurally abnormal. Lower success rates at inducing remission in AE are associated with increased risk of relapse during long-term follow-up. The Eczema Area Severity Index ( EASI) has been agreed as the preferred core instrument to measure clinical signs in future research. There remains a lack of consensus on the definition of an AE flare. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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