1. THE SPECIFICITY OF SKIN-SENSITIZING ANTIBODIES IN THE GUINEA-PIG.
- Author
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van Es, L., Den Harink, Hermina, and Pondman, K. W.
- Subjects
- *
IMMUNOGLOBULINS , *GUINEA pigs , *BLOOD proteins , *IMMUNE serums , *IMMUNOGLOBULIN G , *CHROMATOGRAPHIC analysis - Abstract
In this paper the specificity of the skin-reactive guinea-pig immunoglobulin in the homologous PCA test has been reconsidered. Extensive purification of this immunoglobulin by chromatographic methods results in the isolation of a small fraction or medium speed immunoglobulins that contains all skin reactivity. No correlation could be found with the 7S immunoglobulins IgGγ1 and Igγ1A suggesting a separate class of biologically active immunoglobulins. The PCA active antibody belongs to either an IgG subclass or is a heat stable homocytotropic antibody. Rabbit and chicken antisera against isolated fractions of guinea-pig immunoglobulins show the existence of 7S subclasses. Some suggestions for a revised nomenclature are given. [ABSTRACT FROM AUTHOR]
- Published
- 1970