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They subsequently safely administered their second COVID-19 vaccination after basophil activation testing with one child suffering mild urticaria after the challenge.[1] The present recommendations suggest that patients who experience immediate allergic reactions to mRNA COVID-19 vaccines should undergo skin testing for the vaccine or its excipients. Over 13 billion Coronavirus disease 2019 (COVID-19) vaccines have been administered worldwide. Diagnostic accuracy of vaccine and vaccine excipient testing in the setting of allergic reactions to COVID-19 vaccines: a systematic review and meta-analysis. [Extracted from the article]