1. Deregulation of apolipoprotein C2 gene in cancer: A potential metabolic vulnerability.
- Author
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Liu, Yuqiao, Meng, Yiting, Zhang, Tian, and Alachkar, Houda
- Subjects
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CANCER genes , *MEDICAL libraries , *BREAST , *METHYLGUANINE , *HYPOPHARYNX , *REGULATORY T cells , *NON-small-cell lung carcinoma , *GENETIC regulation , *APOLIPOPROTEIN C - Abstract
Lipid metabolism is elevated in cancer to satisfy increased energy demands.2 Considering APOC2's known function in FA transport and metabolism, its upregulation is a plausible mechanism for cancer adaptation and growth. APOC2, cancer, lipid metabolism Keywords: APOC2; cancer; lipid metabolism EN APOC2 cancer lipid metabolism 1 5 5 07/01/21 20210601 NES 210601 Abbreviations AML acute myeloid leukemia APOC2 apolipoprotein C2 FA fatty acid OS overall survival Dear Editor, Apolipoprotein C2 (APOC2), an activator of lipoprotein lipase, participates in hydrolysis of triglycerides, very low-density lipoproteins, and high-density lipoproteins to release free fatty acids (FA).1 FA oxidation has emerged as an important source of energy for cancer survival and growth.2 Patterns of I APOC2 i genomics and transcriptomic alterations in cancer remained unexplored. [Extracted from the article]
- Published
- 2021
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