Yang, Kaiying, Xiao, Qi, Wang, Kun, Zhao, Jie, Hou, Rongyao, Pan, Xudong, and Zhu, Xiaoyan
Exosomal tsRNAs, with their more stable properties and traceability, show great potential as biomarkers for disease diagnosis.[[3]] Hence, by comparing exosomal tsRNA levels in different types of IS, we indicated that targeting circulating exosomal tsRNAs is a potential strategy for LAA stroke diagnosis, short-term prognosis assessment and plaque stability detection, superior to detecting plasma tsRNAs. Ischemic stroke (IS) occurrence increased the most (226.5%) among all types of strokes from 1990 to 2019.[1] Meanwhile, large-artery atherosclerotic (LAA) stroke forms the most significant proportion of IS.[2] Advanced neuroimaging technologies have been widely applied to diagnose stroke; however, MRIs, which are more accurate, are only readily available in some centres. [Extracted from the article]