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Your search keyword '"R. Beattie"' showing total 4 results
Start Over Author "R. Beattie" Journal clinical and experimental immunology
4 results on '"R. Beattie"'

1. Recovery of antibody production after HIV infection in 'common' variable hypogammaglobulinaemia

Author

A D, Webster, A, Lever, G, Spickett, R, Beattie, M, North, and R, Thorpe

Subjects
Adult, Male, B-Lymphocytes, Agammaglobulinemia, hemic and lymphatic diseases, HIV Seropositivity, HIV-1, virus diseases, Humans, HIV Antibodies, Hepatitis B Antibodies, Lymphocyte Activation, Research Article
Abstract

A patient with a history of at least 10 years 'common' variable hypogammaglobulinaemia seroconverted to HIV-1 and became hypergammaglobulinaemic. The HIV isolated from his blood did not polyclonally activate B cells from normal donors. The mechanism of the hypergammaglobulinaemia is discussed.

Published
1989

2. Role of retroviruses in acquired hypogammaglobulinaemia

Author

G P, Spickett, M, Millrain, R, Beattie, M, North, J, Griffiths, S, Patterson, and A D, Webster

Subjects
Adult, Male, Microscopy, Electron, Retroviridae, Cytopathogenic Effect, Viral, Agammaglobulinemia, viruses, Leukocytes, Mononuclear, Humans, Female, RNA-Directed DNA Polymerase, Research Article
Abstract

Mononuclear cells were obtained from 42 patients with 'common variable' hypogammaglobulinaemia (CVH) and co-cultured with various cell lines in an attempt to isolate retroviruses. Cultures from only two patients showed evidence of a viral infection, although the virus could not be isolated and characterized in either. Despite the previous isolation of HIV's from two other CVH patients, this data suggests that similar viruses are not etiologically involved in the majority of patients.

Published
1988

3. Role of retroviruses in acquired hypogammaglobulinaemia.

Author

Spickett GP, Millrain M, Beattie R, North M, Griffiths J, Patterson S, and Webster AD

Subjects
Adult, Agammaglobulinemia pathology, Cytopathogenic Effect, Viral, Female, Humans, Leukocytes, Mononuclear enzymology, Leukocytes, Mononuclear microbiology, Leukocytes, Mononuclear ultrastructure, Male, Microscopy, Electron, RNA-Directed DNA Polymerase analysis, Agammaglobulinemia microbiology, Retroviridae isolation & purification
Abstract

Mononuclear cells were obtained from 42 patients with 'common variable' hypogammaglobulinaemia (CVH) and co-cultured with various cell lines in an attempt to isolate retroviruses. Cultures from only two patients showed evidence of a viral infection, although the virus could not be isolated and characterized in either. Despite the previous isolation of HIV's from two other CVH patients, this data suggests that similar viruses are not etiologically involved in the majority of patients.

Published
1988

4. Recovery of antibody production after HIV infection in 'common' variable hypogammaglobulinaemia.

Author

Webster AD, Lever A, Spickett G, Beattie R, North M, and Thorpe R

Subjects
Adult, Agammaglobulinemia complications, B-Lymphocytes immunology, Humans, Lymphocyte Activation, Male, Agammaglobulinemia immunology, HIV Antibodies biosynthesis, HIV Seropositivity complications, HIV-1 immunology, Hepatitis B Antibodies biosynthesis
Abstract

A patient with a history of at least 10 years 'common' variable hypogammaglobulinaemia seroconverted to HIV-1 and became hypergammaglobulinaemic. The HIV isolated from his blood did not polyclonally activate B cells from normal donors. The mechanism of the hypergammaglobulinaemia is discussed.

Published
1989

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