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Your search keyword '"SHIBATA, TOMOYUKI"' showing total 12 results
Start Over Author "SHIBATA, TOMOYUKI" Journal clinical and experimental medicine
12 results on '"SHIBATA, TOMOYUKI"'

1. Methylation status of IGF2 DMR and LINE1 in leukocyte DNA provides distinct clinicopathological features of gastric cancer patients

Author

Tahara, Tomomitsu, Tahara, Sayumi, Horiguchi, Noriyuki, Kawamura, Tomohiko, Okubo, Masaaki, Yamada, Hyuga, Yoshida, Dai, Ohmori, Takafumi, Maeda, Kohei, Komura, Naruomi, Ikuno, Hirokazu, Jodai, Yasutaka, Kamano, Toshiaki, Nagasaka, Mitsuo, Nakagawa, Yoshihito, Tsukamoto, Tetsuya, Urano, Makoto, Shibata, Tomoyuki, Kuroda, Makoto, and Ohmiya, Naoki

Published
2018
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7. Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC)

Author

Tahara, Tomomitsu, Shibata, Tomoyuki, Nakamura, Masakatsu, Yamashita, Hiromi, Yoshioka, Daisuke, Okubo, Masaaki, Maruyama, Naoko, Kamano, Toshiaki, Kamiya, Yoshio, Fujita, Hiroshi, Nakagawa, Yoshihito, Nagasaka, Mitsuo, Iwata, Masami, Takahama, Kazuya, Watanabe, Makoto, Nakano, Hiroshi, Hirata, Ichiro, and Arisawa, Tomiyasu

Published
2009
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8. Methylation status of IGF2 DMR and LINE1 in leukocyte DNA provides distinct clinicopathological features of gastric cancer patients

Author

Tahara, Tomomitsu, primary, Tahara, Sayumi, additional, Horiguchi, Noriyuki, additional, Kawamura, Tomohiko, additional, Okubo, Masaaki, additional, Yamada, Hyuga, additional, Yoshida, Dai, additional, Ohmori, Takafumi, additional, Maeda, Kohei, additional, Komura, Naruomi, additional, Ikuno, Hirokazu, additional, Jodai, Yasutaka, additional, Kamano, Toshiaki, additional, Nagasaka, Mitsuo, additional, Nakagawa, Yoshihito, additional, Tsukamoto, Tetsuya, additional, Urano, Makoto, additional, Shibata, Tomoyuki, additional, Kuroda, Makoto, additional, and Ohmiya, Naoki, additional

Published
2017
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10. Telomere length in non-neoplastic colonic mucosa in ulcerative colitis (UC) and its relationship to the severe clinical phenotypes

Author

Tahara, Tomomitsu, primary, Shibata, Tomoyuki, additional, Okubo, Masaaki, additional, Kawamura, Tomohiko, additional, Sumi, Kazuya, additional, Ishizuka, Takamitsu, additional, Nakamura, Masakatsu, additional, Nagasaka, Mitsuo, additional, Nakagawa, Yoshihito, additional, Ohmiya, Naoki, additional, Arisawa, Tomiyasu, additional, and Hirata, Ichiro, additional

Published
2014
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12. Telomere length in the gastric mucosa after Helicobacter pylori eradication and its potential role in the gastric carcinogenesis.

Author

Tahara T, Tahara S, Tuskamoto T, Horiguchi N, Kawamura T, Okubo M, Ishizuka T, Nagasaka M, Nakagawa Y, Shibata T, Kuroda M, and Ohmiya N

Subjects
Adult, Aged, Aged, 80 and over, Biometry, Biopsy, Female, Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Carcinogenesis, Gastric Mucosa pathology, Helicobacter Infections complications, Helicobacter Infections drug therapy, Helicobacter pylori drug effects, Stomach Neoplasms pathology, Telomere
Abstract

The molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication remain unclear. We examined the telomere length of gastric mucosa samples after successful H. pylori eradication in patients without and those with gastric cancer. Telomere length was measured by the real-time PCR among four different groups of biopsies: gastric body from subjects without history of H. pylori infection (Hp-: n = 23), gastric body from cancer-free subjects after H. pylori eradication (cancer-free body: n = 24), gastric body from early gastric cancer patients diagnosed after H. pylori eradication (EGC body: n = 35) and its paired samples from adjacent mucosa of cancerous area (EGC ADJ: n = 35). The Hp-group presented the longest telomeres among the all groups (Hp- vs. all others, all P < 0.05). Samples from EGC body group showed shorter telomere length than the samples from cancer-free body groups (P < 0.05). Conversely, samples from EGC ADJ group showed rather longer telomere length compared to the EGC body group (P < 0.05), which was also confirmed by the comparison of 35 matched samples (P = 0.0007). Among the samples after H. pylori eradication, shorter telomere length was associated with higher expression of IL-1B and NF-kB (P < 0.0001, 0.0006, respectively). Longer telomere length was also associated with higher expression of TNF-A (P = 0.01). Telomere shortening seems to be important initial steps in gastric cancer predisposition after H. pylori eradication, while it might shift to lengthening to acquire more aggressive pathway to develop cancer.

Published
2018
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