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1. Concurrent validity, cut‐offs and ability to change of patient‐reported outcome measures for rhinitis and asthma in MASK‐air®

Author

Jean Bousquet, Bernardo Sousa‐Pinto, Josep M. Anto, Anna Bedbrook, Wienczyslawa Czarlewski, Ignacio J. Ansotegui, Karl‐C. Bergmann, Fulvio Braido, Luisa Brussino, Lorenzo Cecchi, Claudia Chaves Loureiro, Alvaro A. Cruz, Philippe Devillier, Alessandro Fiocchi, Bilun Gemicioglu, Tari Haahtela, Juan Carlos Ivancevich, Ludger Klimek, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Violeta Kvedariene, Desiree E. Larenas‐Linnemann, Gilles Louis, Renaud Louis, Michael Makris, Mario Morais‐Almeida, Marek Niedoszytko, Ken Ohta, Markus Ollert, Nikolaos Papadopoulos, Vincenzo Patella, Benoit Pétré, Oliver Pfaar, Francesca Puggioni, Santiago Quirce, Frederico S. Regateiro, Nicolas Roche, Philip W. Rouadi, Boleslaw Samolinski, Joaquin Sastre, Florence Schleich, Nicola Scichilone, Luis Taborda‐Barata, Sanna Toppila‐Salmi, Arunas Valiulis, Ilgim Vardaloglu Koyuncu, Maria Teresa Ventura, Arzu Yorgancioglu, Joao A. Fonseca, and Torsten Zuberbier

Subjects
asthma, digital health, EQ‐5D, rhinitis, visual analogue scale, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Patient‐reported outcome measures (PROMs) are used to assess a patient's health status at a particular point in time. They are essential in the development of person‐centred care. This paper reviews studies performed on PROMs for assessing AR and asthma control, in particular VAS scales that are included in the app MASK‐air® (Mobile Airways Sentinel networK) for asthma and rhinitis. VASs were initially developed on paper and pencil and tested for their criterion validity, cut‐offs and responsiveness. Then, a multicentric, multinational, double‐blind, placebo‐controlled, randomised control trial (DB‐PC‐RCT) using an electronic VAS form was carried out. Finally, with the development of MASK‐air® in 2015, previously validated VAS questions were adapted to the digital format and further methodologic evaluations were performed. VAS for asthma, rhinitis, conjunctivitis, work and EQ‐5D are included in the app. Additionally, two control‐medication scores for allergic symptoms of asthma (e‐DASTHMA) were validated for their criterion validity, cut‐offs and responsiveness.

Published
2024
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2. Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK‐air study

Author

Bernardo Sousa‐Pinto, Gilles Louis, Rafael J. Vieira, Wienczyslawa Czarlewski, Josep M. Anto, Rita Amaral, Ana Sá‐Sousa, Luisa Brussino, G. Walter Canonica, Claudia Chaves Loureiro, Alvaro A. Cruz, Bilun Gemicioglu, Tari Haahtela, Maciej Kupczyk, Violeta Kvedariene, Desirée E. Larenas‐Linnemann, Nhân Pham‐Thi, Francesca Puggioni, Frederico S. Regateiro, Jan Romantowski, Joaquin Sastre, Nicola Scichilone, Luis Taborda‐Barata, Maria Teresa Ventura, Ioana Agache, Anna Bedbrook, Alida Benfante, Karl C. Bergmann, Sinthia Bosnic‐Anticevich, Matteo Bonini, Louis‐Philippe Boulet, Guy Brusselle, Roland Buhl, Lorenzo Cecchi, Denis Charpin, Elisio M. Costa, Stefano Del Giacco, Marek Jutel, Ludger Klimek, Piotr Kuna, Daniel Laune, Mika Makela, Mario Morais‐Almeida, Rachel Nadif, Marek Niedoszytko, Nikolaos G. Papadopoulos, Alberto Papi, Oliver Pfaar, Daniela Rivero‐Yeverino, Nicolas Roche, Boleslaw Samolinski, Mohamed H. Shamji, Aziz Sheikh, Charlotte Suppli Ulrik, Omar S. Usmani, Arunas Valiulis, Arzu Yorgancioglu, Torsten Zuberbier, Joao A. Fonseca, Benoit Pétré, Renaud Louis, Jean Bousquet, and MASK‐air think tank

Subjects
asthma, diagnosis, dyspnea, mHealth, wheezing, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Rationale It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods In this cross‐sectional study, we assessed real‐world data using the MASK‐air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e‐DASTHMA score). Results were validated in a sample of patients with a physician‐established diagnosis of asthma. Measurement and Main Results We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e‐DASTHMA. Consistent results were observed when assessing patients with a physician‐made diagnosis of asthma. Conclusions Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.

Published
2024
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4. Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air® approach

Author

Jean Bousquet, Josep M. Anto, Bernardo Sousa‐Pinto, Wienczyslawa Czarlewski, Anna Bedbrook, Tari Haahtela, Ludger Klimek, Oliver Pfaar, Piotr Kuna, Maciej Kupczyk, Frederico S. Regateiro, Boleslaw Samolinski, Arunas Valiulis, Arzu Yorgancioglu, Sylvie Arnavielhe, Xavier Basagaña, Karl C. Bergmann, Sinthia Bosnic‐Anticevich, Luisa Brussino, G. Walter Canonica, Victoria Cardona, Lorenzo Cecchi, Claudia Chaves‐Loureiro, Elisio Costa, Alvaro A. Cruz, Bilun Gemicioglu, Wytske J. Fokkens, Juan Carlos Ivancevich, Helga Kraxner, Violeta Kvedariene, Désirée E. Larenas‐Linnemann, Daniel Laune, Renaud Louis, Michael Makris, Marcus Maurer, Erik Melén, Yann Micheli, Mario Morais‐Almeida, Joaquim Mullol, Marek Niedoszytko, Yoshitaka Okamoto, Nikolaos G. Papadopoulos, Vincenzo Patella, Nhân Pham‐Thi, Philip W. Rouadi, Joaquin Sastre, Nicola Scichilone, Aziz Sheikh, Mikhail Sofiev, Luis Taborda‐Barata, Sanna Toppila‐Salmi, Ioanna Tsiligianni, Erkka Valovirta, Maria Teresa Ventura, Rafael José Vieira, Mihaela Zidarn, Rita Amaral, Ignacio J. Ansotegui, Annabelle Bédard, Samuel Benveniste, Michael Bewick, Carsten Bindslev‐Jensen, Hubert Blain, Matteo Bonini, Rodolphe Bourret, Fulvio Braido, Pedro Carreiro‐Martins, Denis Charpin, Ivan Cherrez‐Ojeda, Tomas Chivato, Derek K. Chu, Cemal Cingi, Stefano DelGiacco, Frédéric deBlay, Philippe Devillier, Govert DeVries, Maria Doulaptsi, Virginie Doyen, Gérard Dray, Jean‐François Fontaine, R. Maximiliano Gomez, Jan Hagemann, Enrico Heffler, Maja Hofmann, Ewa Jassem, Marek Jutel, Thomas Keil, Vicky Kritikos, Inger Kull, Marek Kulus, Olga Lourenço, Eve Mathieu‐Dupas, Enrica Menditto, Ralph Mösges, Ruth Murray, Rachel Nadif, Hugo Neffen, Stefania Nicola, Robyn O’Hehir, Heidi Olze, Yuliia Palamarchuk, Jean‐Louis Pépin, Benoit Pétré, Robert Picard, Constantinos Pitsios, Francesca Puggioni, Santiago Quirce, Filip Raciborski, Sietze Reitsma, Nicolas Roche, Monica Rodriguez‐Gonzalez, Jan Romantowski, Ana Sá‐Sousa, Faradiba S. Serpa, Marine Savouré, Mohamed H. Shamji, Milan Sova, Annette Sperl, Cristiana Stellato, Ana Todo‐Bom, Peter Valentin Tomazic, Olivier Vandenplas, Michiel VanEerd, Tuula Vasankari, Frédéric Viart, Susan Waserman, Joao A. Fonseca, and Torsten Zuberbier

Subjects
asthma, digital, MASK‐air, mHealth, rhinitis, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract MASK‐air®, a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK‐air® is a Good Practice of DG Santé on digitally‐enabled, patient‐centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co‐operation and Development). MASK‐air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK‐air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as‐needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom‐medication score (ARIA‐EAACI‐CSMS) has been validated for clinical practice and trials. The implications of the novel MASK‐air® results should lead to change management in rhinitis and asthma.

Published
2023
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5. Real‐world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities

Author

Bernardo Sousa‐Pinto, Aram Anto, Markus Berger, Stephanie Dramburg, Oliver Pfaar, Ludger Klimek, Marek Jutel, Wienczyslawa Czarlewski, Anna Bedbrook, Arunas Valiulis, Ioana Agache, Rita Amaral, Ignacio J. Ansotegui, Katharina Bastl, Uwe Berger, Karl C. Bergmann, Sinthia Bosnic‐Anticevich, Fulvio Braido, Luisa Brussino, Victoria Cardona, Thomas Casale, G. Walter Canonica, Lorenzo Cecchi, Denis Charpin, Tomás Chivato, Derek K. Chu, Cemal Cingi, Elisio M. Costa, Alvaro A. Cruz, Philippe Devillier, Stephen R. Durham, Motohiro Ebisawa, Alessandro Fiocchi, Wytske J. Fokkens, Bilun Gemicioğlu, Maia Gotua, Maria‐Antonieta Guzmán, Tari Haahtela, Juan Carlos Ivancevich, Piotr Kuna, Igor Kaidashev, Musa Khaitov, Violeta Kvedariene, Désirée E. Larenas‐Linnemann, Brian Lipworth, Daniel Laune, Paolo M. Matricardi, Mario Morais‐Almeida, Joaquim Mullol, Robert Naclerio, Hugo Neffen, Kristoff Nekam, Marek Niedoszytko, Yoshitaka Okamoto, Nikolaos G. Papadopoulos, Hae‐Sim Park, Giovanni Passalacqua, Vincenzo Patella, Simone Pelosi, Nhân Pham‐Thi, Ted A. Popov, Frederico S. Regateiro, Sietze Reitsma, Monica Rodriguez‐Gonzales, Nelson Rosario, Philip W. Rouadi, Boleslaw Samolinski, Ana Sá‐Sousa, Joaquin Sastre, Aziz Sheikh, Charlotte Suppli Ulrik, Luis Taborda‐Barata, Ana Todo‐Bom, Peter Valentin Tomazic, Sanna Toppila‐Salmi, Salvatore Tripodi, Ioanna Tsiligianni, Erkka Valovirta, Maria Teresa Ventura, Antonio A. Valero, Rafael José Vieira, Dana Wallace, Susan Waserman, Sian Williams, Arzu Yorgancioglu, Luo Zhang, Mihaela Zidarn, Jaron Zuberbier, Heidi Olze, Josep M. Antó, Torsten Zuberbier, João A. Fonseca, and Jean Bousquet

Subjects
allergic rhinitis, app, chronic rhinosinusitis, mHealth, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Digital health is an umbrella term which encompasses eHealth and benefits from areas such as advanced computer sciences. eHealth includes mHealth apps, which offer the potential to redesign aspects of healthcare delivery. The capacity of apps to collect large amounts of longitudinal, real‐time, real‐world data enables the progression of biomedical knowledge. Apps for rhinitis and rhinosinusitis were searched for in the Google Play and Apple App stores, via an automatic market research tool recently developed using JavaScript. Over 1500 apps for allergic rhinitis and rhinosinusitis were identified, some dealing with multimorbidity. However, only six apps for rhinitis (AirRater, AllergyMonitor, AllerSearch, Husteblume, MASK‐air and Pollen App) and one for rhinosinusitis (Galenus Health) have so far published results in the scientific literature. These apps were reviewed for their validation, discovery of novel allergy phenotypes, optimisation of identifying the pollen season, novel approaches in diagnosis and management (pharmacotherapy and allergen immunotherapy) as well as adherence to treatment. Published evidence demonstrates the potential of mobile health apps to advance in the characterisation, diagnosis and management of rhinitis and rhinosinusitis patients.

Published
2022
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6. Validity, reliability, and responsiveness of daily monitoring visual analog scales in MASK‐air®

Author

Bernardo Sousa‐Pinto, Patrik Eklund, Oliver Pfaar, Ludger Klimek, Torsten Zuberbier, Wienczyslawa Czarlewski, Annabelle Bédard, Carsten Bindslev‐Jensen, Anna Bedbrook, Sinthia Bosnic‐Anticevich, Luisa Brussino, Victoria Cardona, Alvaro A. Cruz, Govert deVries, Philippe Devillier, Wytske J. Fokkens, José Miguel Fuentes‐Pérez, Bilun Gemicioğlu, Tari Haahtela, Yunen Rocío Huerta‐Villalobos, Juan Carlos Ivancevich, Inger Kull, Piotr Kuna, Violeta Kvedariene, Désirée E. Larenas Linnemann, Daniel Laune, Michael Makris, Erik Melén, Mário Morais‐Almeida, Ralph Mösges, Joaquim Mullol, Robyn E. O'Hehir, Nikolaos G. Papadopoulos, Ana Margarida Pereira, Emmanuel P. Prokopakis, Fotis Psarros, Frederico S. Regateiro, Sietze Reitsma, Boleslaw Samolinski, Nicola Scichilone, Jane daSilva, Cristiana Stellato, Ana Todo‐Bom, Peter Valentin Tomazic, Sanna Toppila Salmi, Antonio Valero, Arunas Valiulis, Erkka Valovirta, Michiel vanEerd, Maria Teresa Ventura, Arzu Yorgancioglu, Xavier Basagaña, Josep M. Antó, Jean Bousquet, and João Almeida Fonseca

Subjects
allergic rhinitis, mobile health, reliability, responsiveness, visual analog scales, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background MASK‐air® is an app that supports allergic rhinitis patients in disease control. Users register daily allergy symptoms and their impact on activities using visual analog scales (VASs). We aimed to assess the concurrent validity, reliability, and responsiveness of these daily VASs. Methods Daily monitoring VAS data were assessed in MASK‐air® users with allergic rhinitis. Concurrent validity was assessed by correlating daily VAS values with those of the EuroQol‐5 Dimensions (EQ‐5D) VAS, the Control of Allergic Rhinitis and Asthma Test (CARAT) score, and the Work Productivity and Activity Impairment Allergic Specific (WPAI‐AS) Questionnaire (work and activity impairment scores). Intra‐rater reliability was assessed in users providing multiple daily VASs within the same day. Test–retest reliability was tested in clinically stable users, as defined by the EQ‐5D VAS, CARAT, or “VAS Work” (i.e., VAS assessing the impact of allergy on work). Responsiveness was determined in users with two consecutive measurements of EQ‐5D‐VAS or “VAS Work” indicating clinical change. Results A total of 17,780 MASK‐air® users, with 317,176 VAS days, were assessed. Concurrent validity was moderate–high (Spearman correlation coefficient range: 0.437–0.716). Intra‐rater reliability intraclass correlation coefficients (ICCs) ranged between 0.870 (VAS assessing global allergy symptoms) and 0.937 (VAS assessing allergy symptoms on sleep). Test–retest reliability ICCs ranged between 0.604 and 0.878—“VAS Work” and “VAS asthma” presented the highest ICCs. Moderate/large responsiveness effect sizes were observed—the sleep VAS was associated with lower responsiveness, while the global allergy symptoms VAS demonstrated higher responsiveness. Conclusion In MASK‐air®, daily monitoring VASs have high intra‐rater reliability and moderate–high validity, reliability, and responsiveness, pointing to a reliable measure of symptom loads.

Published
2021
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7. ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy

Author

Jean Bousquet, Oliver Pfaar, Ioana Agache, Anna Bedbrook, Cezmi A Akdis, G. Walter Canonica, Tomas Chivato, Mona Al‐Ahmad, Amir H Abdul Latiff, Ignacio J Ansotegui, Claus Bachert, Abdullah Baharuddin, Karl‐Christian Bergmann, Carsten Bindslev‐Jensen, Leif Bjermer, Matteo Bonini, Sinthia Bosnic‐Anticevich, Isabelle Bosse, Helen A. Brough, Luisa Brussino, Moises A Calderon, Luis Caraballo, Victoria Cardona, Pedro Carreiro‐Martins, Tomas Casale, Lorenzo Cecchi, Alfonso M Cepeda Sarabia, Ekaterine Chkhartishvili, Derek K Chu, Ieva Cirule, Alvaro A Cruz, Wienczyslawa Czarlewski, Stefano delGiacco, Pascal Demoly, Philippe Devillier, Dejan Dokic, Stephen L Durham, Motohiro Ebisawa, Yehia El‐Gamal✝, Regina Emuzyte, Amiran Gamkrelidze, Jean Luc Fauquert, Alessandro Fiocchi, Wytske J Fokkens, Joao A Fonseca, Jean‐François Fontaine, Radoslaw Gawlik, Asli Gelincik, Bilun Gemicioglu, Jose E Gereda, Roy Gerth van Wijk, R Maximiliano Gomez, Maia Gotua, Ineta Grisle, Maria‐Antonieta Guzmán, Tari Haahtela, Susanne Halken, Enrico Heffler, Karin Hoffmann‐Sommergruber, Elham Hossny, Martin Hrubiško, Carla Irani, Juan Carlos Ivancevich, Zhanat Ispayeva, Kaja Julge, Igor Kaidashev, Omer Kalayci, Musa Khaitov, Ludger Klimek, Edward Knol, Marek L Kowalski, Helga Kraxner, Inger Kull, Piotr Kuna, Violeta Kvedariene, Vicky Kritikos, Antti Lauerma, Susanne Lau, Daniel Laune, Michael Levin, Desiree E Larenas‐Linnemann, Karin C Lodrup Carlsen, Carlo Lombardi, Olga M Lourenço, Bassam Mahboub, Hans‐Jørgen Malling, Patrick Manning, Gailen D Marshall, Erik Melén, Eli O Meltzer, Neven Miculinic, Branislava Milenkovic, Mostafa Moin, Stephen Montefort, Mario Morais‐Almeida, Charlotte G Mortz, Ralph Mösges, Joaquim Mullol, Leyla Namazova Baranova, Hugo Neffen, Kristof Nekam, Marek Niedoszytko, Mikaëla Odemyr, Robyn E O'Hehir, Markus Ollert, Liam O'Mahony, Ken Ohta, Yoshitaka Okamoto, Kimi Okubo, Giovanni B Pajno, Oscar Palomares, Susanna Palkonen, Petr Panzner, Nikolaos GPapadopoulos, Hae‐Sim Park, Giovanni Passalacqua, Vincenzo Patella, Ruby Pawankar, Nhân Pham‐Thi, Davor Plavec, Todor A Popov, Marysia Recto, Frederico S Regateiro, Carmen Riggioni, Graham Roberts, Monica Rodriguez‐Gonzales, Nelson Rosario, Menachem Rottem, Philip W Rouadi, Dermot Ryan, Boleslaw Samolinski, Mario Sanchez‐Borges✝, Faradiba S Serpa, Joaquin Sastre, Glenis K. Scadding, Mohamed H Shamji, Peter Schmid‐Grendelmeier, Holger J Schünemann, Aziz Sheikh, Nicola Scichilone, Juan Carlos Sisul, Mikhail Sofiev, Dirceu Solé, Talant Sooronbaev, Manuel Soto‐Martinez, Manuel Soto‐Quiros, Milan Sova, Jürgen Schwarze, Isabel Skypala, Charlotte Suppli‐Ulrik, Luis Taborda‐Barata, Ana Todo‐Bom, Maria J Torres, Marylin Valentin‐Rostan, Peter‐Valentin Tomazic, Antonio Valero, Sanna Toppila‐Salmi, Ioanna Tsiligianni, Eva Untersmayr, Marilyn Urrutia‐Pereira, Arunas Valiulis, Erkka Valovirta, Olivier Vandenplas, Maria Teresa Ventura, Pakit Vichyanond, Martin Wagenmann, Dana Wallace, Jolanta Walusiak‐Skorupa, De Yun Wang, Susan Waserman, Gary WK Wong, Arzu Yorgancioglu, Osman M Yusuf, Mario Zernotti, Luo Zhang, Mihaela Zidarn, Torsten Zuberbier, and Marek Jutel

Subjects
allergic rhinitis, asthma, immunotherapy, precision medicine, Immunologic diseases. Allergy, RC581-607
Published
2021
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8. MASK‐air ® real‐world data in respiratory allergy in old‐age adults

Author

Taborda‐Barata, Luis, primary, Ventura, Maria Teresa, additional, Blain, Hubert, additional, Brussino, Luisa, additional, Kvedariene, Violeta, additional, Larenas‐Linneman, Désirée E., additional, Pham‐Thi, Nhân, additional, Samolinski, Boleslaw, additional, Fonseca, Joao A., additional, Bousquet, Jean, additional, and Sousa‐Pinto, Bernardo, additional

Published
2023
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9. Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air ® approach

Author

Bousquet, Jean, primary, Anto, Josep M., additional, Sousa‐Pinto, Bernardo, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Haahtela, Tari, additional, Klimek, Ludger, additional, Pfaar, Oliver, additional, Kuna, Piotr, additional, Kupczyk, Maciej, additional, Regateiro, Frederico S., additional, Samolinski, Boleslaw, additional, Valiulis, Arunas, additional, Yorgancioglu, Arzu, additional, Arnavielhe, Sylvie, additional, Basagaña, Xavier, additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Brussino, Luisa, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Cecchi, Lorenzo, additional, Chaves‐Loureiro, Claudia, additional, Costa, Elisio, additional, Cruz, Alvaro A., additional, Gemicioglu, Bilun, additional, Fokkens, Wytske J., additional, Ivancevich, Juan Carlos, additional, Kraxner, Helga, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Laune, Daniel, additional, Louis, Renaud, additional, Makris, Michael, additional, Maurer, Marcus, additional, Melén, Erik, additional, Micheli, Yann, additional, Morais‐Almeida, Mario, additional, Mullol, Joaquim, additional, Niedoszytko, Marek, additional, Okamoto, Yoshitaka, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Rouadi, Philip W., additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Sheikh, Aziz, additional, Sofiev, Mikhail, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Valovirta, Erkka, additional, Ventura, Maria Teresa, additional, Vieira, Rafael José, additional, Zidarn, Mihaela, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bédard, Annabelle, additional, Benveniste, Samuel, additional, Bewick, Michael, additional, Bindslev‐Jensen, Carsten, additional, Blain, Hubert, additional, Bonini, Matteo, additional, Bourret, Rodolphe, additional, Braido, Fulvio, additional, Carreiro‐Martins, Pedro, additional, Charpin, Denis, additional, Cherrez‐Ojeda, Ivan, additional, Chivato, Tomas, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Del Giacco, Stefano, additional, de Blay, Frédéric, additional, Devillier, Philippe, additional, De Vries, Govert, additional, Doulaptsi, Maria, additional, Doyen, Virginie, additional, Dray, Gérard, additional, Fontaine, Jean‐François, additional, Gomez, R. Maximiliano, additional, Hagemann, Jan, additional, Heffler, Enrico, additional, Hofmann, Maja, additional, Jassem, Ewa, additional, Jutel, Marek, additional, Keil, Thomas, additional, Kritikos, Vicky, additional, Kull, Inger, additional, Kulus, Marek, additional, Lourenço, Olga, additional, Mathieu‐Dupas, Eve, additional, Menditto, Enrica, additional, Mösges, Ralph, additional, Murray, Ruth, additional, Nadif, Rachel, additional, Neffen, Hugo, additional, Nicola, Stefania, additional, O’Hehir, Robyn, additional, Olze, Heidi, additional, Palamarchuk, Yuliia, additional, Pépin, Jean‐Louis, additional, Pétré, Benoit, additional, Picard, Robert, additional, Pitsios, Constantinos, additional, Puggioni, Francesca, additional, Quirce, Santiago, additional, Raciborski, Filip, additional, Reitsma, Sietze, additional, Roche, Nicolas, additional, Rodriguez‐Gonzalez, Monica, additional, Romantowski, Jan, additional, Sá‐Sousa, Ana, additional, Serpa, Faradiba S., additional, Savouré, Marine, additional, Shamji, Mohamed H., additional, Sova, Milan, additional, Sperl, Annette, additional, Stellato, Cristiana, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Vandenplas, Olivier, additional, Van Eerd, Michiel, additional, Vasankari, Tuula, additional, Viart, Frédéric, additional, Waserman, Susan, additional, Fonseca, Joao A., additional, and Zuberbier, Torsten, additional

Published
2023
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10. Real‐world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities

Author

Sousa‐Pinto, Bernardo, primary, Anto, Aram, additional, Berger, Markus, additional, Dramburg, Stephanie, additional, Pfaar, Oliver, additional, Klimek, Ludger, additional, Jutel, Marek, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Valiulis, Arunas, additional, Agache, Ioana, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bastl, Katharina, additional, Berger, Uwe, additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Braido, Fulvio, additional, Brussino, Luisa, additional, Cardona, Victoria, additional, Casale, Thomas, additional, Canonica, G. Walter, additional, Cecchi, Lorenzo, additional, Charpin, Denis, additional, Chivato, Tomás, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elisio M., additional, Cruz, Alvaro A., additional, Devillier, Philippe, additional, Durham, Stephen R., additional, Ebisawa, Motohiro, additional, Fiocchi, Alessandro, additional, Fokkens, Wytske J., additional, Gemicioğlu, Bilun, additional, Gotua, Maia, additional, Guzmán, Maria‐Antonieta, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Lipworth, Brian, additional, Laune, Daniel, additional, Matricardi, Paolo M., additional, Morais‐Almeida, Mario, additional, Mullol, Joaquim, additional, Naclerio, Robert, additional, Neffen, Hugo, additional, Nekam, Kristoff, additional, Niedoszytko, Marek, additional, Okamoto, Yoshitaka, additional, Papadopoulos, Nikolaos G., additional, Park, Hae‐Sim, additional, Passalacqua, Giovanni, additional, Patella, Vincenzo, additional, Pelosi, Simone, additional, Pham‐Thi, Nhân, additional, Popov, Ted A., additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rodriguez‐Gonzales, Monica, additional, Rosario, Nelson, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sá‐Sousa, Ana, additional, Sastre, Joaquin, additional, Sheikh, Aziz, additional, Ulrik, Charlotte Suppli, additional, Taborda‐Barata, Luis, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Toppila‐Salmi, Sanna, additional, Tripodi, Salvatore, additional, Tsiligianni, Ioanna, additional, Valovirta, Erkka, additional, Ventura, Maria Teresa, additional, Valero, Antonio A., additional, Vieira, Rafael José, additional, Wallace, Dana, additional, Waserman, Susan, additional, Williams, Sian, additional, Yorgancioglu, Arzu, additional, Zhang, Luo, additional, Zidarn, Mihaela, additional, Zuberbier, Jaron, additional, Olze, Heidi, additional, Antó, Josep M., additional, Zuberbier, Torsten, additional, Fonseca, João A., additional, and Bousquet, Jean, additional

Published
2022
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11. Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects model

Author

Sousa‐Pinto, Bernardo, primary, Azevedo, Luís Filipe, additional, Sá‐Sousa, Ana, additional, Vieira, Rafael José, additional, Amaral, Rita, additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Anto, Josep M., additional, Bedbrook, Anna, additional, Kvedariene, Violeta, additional, Ventura, Maria Teresa, additional, Ansotegui, Ignacio J., additional, Bergmann, Karl‐Christian, additional, Brussino, Luisa, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Carreiro‐Martins, Pedro, additional, Casale, Thomas, additional, Cecchi, Lorenzo, additional, Chivato, Tomás, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elisio M., additional, Cruz, Alvaro A., additional, De Feo, Giulia, additional, Devillier, Philippe, additional, Fokkens, Wytske J., additional, Gaga, Mina, additional, Gemicioğlu, Bilun, additional, Haahtela, Tari, additional, Ivancevich, Juan Carlos, additional, Ispayeva, Zhanat, additional, Jutel, Marek, additional, Kuna, Piotr, additional, Kaidashev, Igor, additional, Kraxner, Helga, additional, Larenas‐Linnemann, Désirée E., additional, Laune, Daniel, additional, Lipworth, Brian, additional, Louis, Renaud, additional, Makris, Michaël, additional, Monti, Riccardo, additional, Morais‐Almeida, Mario, additional, Mösges, Ralph, additional, Mullol, Joaquim, additional, Odemyr, Mikaëla, additional, Okamoto, Yoshitaka, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Rouadi, Philip W., additional, Samolinski, Boleslaw, additional, Sova, Milan, additional, Todo‐Bom, Ana, additional, Taborda‐Barata, Luis, additional, Tomazic, Peter Valentin, additional, Toppila‐Salmi, Sanna, additional, Sastre, Joaquin, additional, Tsiligianni, Ioanna, additional, Valiulis, Arunas, additional, Wallace, Dana, additional, Waserman, Susan, additional, Yorgancioglu, Arzu, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, Fonseca, João Almeida, additional, Bousquet, Jean, additional, and Pfaar, Oliver, additional

Published
2022
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12. Validity, reliability, and responsiveness of daily monitoring visual analog scales in MASK‐air®

Author

Sousa‐Pinto, Bernardo, primary, Eklund, Patrik, additional, Pfaar, Oliver, additional, Klimek, Ludger, additional, Zuberbier, Torsten, additional, Czarlewski, Wienczyslawa, additional, Bédard, Annabelle, additional, Bindslev‐Jensen, Carsten, additional, Bedbrook, Anna, additional, Bosnic‐Anticevich, Sinthia, additional, Brussino, Luisa, additional, Cardona, Victoria, additional, Cruz, Alvaro A., additional, Vries, Govert, additional, Devillier, Philippe, additional, Fokkens, Wytske J., additional, Fuentes‐Pérez, José Miguel, additional, Gemicioğlu, Bilun, additional, Haahtela, Tari, additional, Huerta‐Villalobos, Yunen Rocío, additional, Ivancevich, Juan Carlos, additional, Kull, Inger, additional, Kuna, Piotr, additional, Kvedariene, Violeta, additional, Larenas Linnemann, Désirée E., additional, Laune, Daniel, additional, Makris, Michael, additional, Melén, Erik, additional, Morais‐Almeida, Mário, additional, Mösges, Ralph, additional, Mullol, Joaquim, additional, O'Hehir, Robyn E., additional, Papadopoulos, Nikolaos G., additional, Pereira, Ana Margarida, additional, Prokopakis, Emmanuel P., additional, Psarros, Fotis, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Samolinski, Boleslaw, additional, Scichilone, Nicola, additional, Silva, Jane, additional, Stellato, Cristiana, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Salmi, Sanna Toppila, additional, Valero, Antonio, additional, Valiulis, Arunas, additional, Valovirta, Erkka, additional, Eerd, Michiel, additional, Ventura, Maria Teresa, additional, Yorgancioglu, Arzu, additional, Basagaña, Xavier, additional, Antó, Josep M., additional, Bousquet, Jean, additional, and Fonseca, João Almeida, additional

Published
2021
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13. ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy

Author

Bousquet, Jean, primary, Pfaar, Oliver, additional, Agache, Ioana, additional, Bedbrook, Anna, additional, Akdis, Cezmi A, additional, Canonica, G. Walter, additional, Chivato, Tomas, additional, Al‐Ahmad, Mona, additional, Abdul Latiff, Amir H, additional, Ansotegui, Ignacio J, additional, Bachert, Claus, additional, Baharuddin, Abdullah, additional, Bergmann, Karl‐Christian, additional, Bindslev‐Jensen, Carsten, additional, Bjermer, Leif, additional, Bonini, Matteo, additional, Bosnic‐Anticevich, Sinthia, additional, Bosse, Isabelle, additional, Brough, Helen A., additional, Brussino, Luisa, additional, Calderon, Moises A, additional, Caraballo, Luis, additional, Cardona, Victoria, additional, Carreiro‐Martins, Pedro, additional, Casale, Tomas, additional, Cecchi, Lorenzo, additional, Cepeda Sarabia, Alfonso M, additional, Chkhartishvili, Ekaterine, additional, Chu, Derek K, additional, Cirule, Ieva, additional, Cruz, Alvaro A, additional, Czarlewski, Wienczyslawa, additional, del Giacco, Stefano, additional, Demoly, Pascal, additional, Devillier, Philippe, additional, Dokic, Dejan, additional, Durham, Stephen L, additional, Ebisawa, Motohiro, additional, El‐Gamal✝, Yehia, additional, Emuzyte, Regina, additional, Gamkrelidze, Amiran, additional, Fauquert, Jean Luc, additional, Fiocchi, Alessandro, additional, Fokkens, Wytske J, additional, Fonseca, Joao A, additional, Fontaine, Jean‐François, additional, Gawlik, Radoslaw, additional, Gelincik, Asli, additional, Gemicioglu, Bilun, additional, Gereda, Jose E, additional, Gerth van Wijk, Roy, additional, Gomez, R Maximiliano, additional, Gotua, Maia, additional, Grisle, Ineta, additional, Guzmán, Maria‐Antonieta, additional, Haahtela, Tari, additional, Halken, Susanne, additional, Heffler, Enrico, additional, Hoffmann‐Sommergruber, Karin, additional, Hossny, Elham, additional, Hrubiško, Martin, additional, Irani, Carla, additional, Ivancevich, Juan Carlos, additional, Ispayeva, Zhanat, additional, Julge, Kaja, additional, Kaidashev, Igor, additional, Kalayci, Omer, additional, Khaitov, Musa, additional, Klimek, Ludger, additional, Knol, Edward, additional, Kowalski, Marek L, additional, Kraxner, Helga, additional, Kull, Inger, additional, Kuna, Piotr, additional, Kvedariene, Violeta, additional, Kritikos, Vicky, additional, Lauerma, Antti, additional, Lau, Susanne, additional, Laune, Daniel, additional, Levin, Michael, additional, Larenas‐Linnemann, Desiree E, additional, Lodrup Carlsen, Karin C, additional, Lombardi, Carlo, additional, Lourenço, Olga M, additional, Mahboub, Bassam, additional, Malling, Hans‐Jørgen, additional, Manning, Patrick, additional, Marshall, Gailen D, additional, Melén, Erik, additional, Meltzer, Eli O, additional, Miculinic, Neven, additional, Milenkovic, Branislava, additional, Moin, Mostafa, additional, Montefort, Stephen, additional, Morais‐Almeida, Mario, additional, Mortz, Charlotte G, additional, Mösges, Ralph, additional, Mullol, Joaquim, additional, Namazova Baranova, Leyla, additional, Neffen, Hugo, additional, Nekam, Kristof, additional, Niedoszytko, Marek, additional, Odemyr, Mikaëla, additional, O'Hehir, Robyn E, additional, Ollert, Markus, additional, O'Mahony, Liam, additional, Ohta, Ken, additional, Okamoto, Yoshitaka, additional, Okubo, Kimi, additional, Pajno, Giovanni B, additional, Palomares, Oscar, additional, Palkonen, Susanna, additional, Panzner, Petr, additional, G Papadopoulos, Nikolaos, additional, Park, Hae‐Sim, additional, Passalacqua, Giovanni, additional, Patella, Vincenzo, additional, Pawankar, Ruby, additional, Pham‐Thi, Nhân, additional, Plavec, Davor, additional, Popov, Todor A, additional, Recto, Marysia, additional, Regateiro, Frederico S, additional, Riggioni, Carmen, additional, Roberts, Graham, additional, Rodriguez‐Gonzales, Monica, additional, Rosario, Nelson, additional, Rottem, Menachem, additional, Rouadi, Philip W, additional, Ryan, Dermot, additional, Samolinski, Boleslaw, additional, Sanchez‐Borges✝, Mario, additional, Serpa, Faradiba S, additional, Sastre, Joaquin, additional, Scadding, Glenis K., additional, Shamji, Mohamed H, additional, Schmid‐Grendelmeier, Peter, additional, Schünemann, Holger J, additional, Sheikh, Aziz, additional, Scichilone, Nicola, additional, Sisul, Juan Carlos, additional, Sofiev, Mikhail, additional, Solé, Dirceu, additional, Sooronbaev, Talant, additional, Soto‐Martinez, Manuel, additional, Soto‐Quiros, Manuel, additional, Sova, Milan, additional, Schwarze, Jürgen, additional, Skypala, Isabel, additional, Suppli‐Ulrik, Charlotte, additional, Taborda‐Barata, Luis, additional, Todo‐Bom, Ana, additional, Torres, Maria J, additional, Valentin‐Rostan, Marylin, additional, Tomazic, Peter‐Valentin, additional, Valero, Antonio, additional, Toppila‐Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Untersmayr, Eva, additional, Urrutia‐Pereira, Marilyn, additional, Valiulis, Arunas, additional, Valovirta, Erkka, additional, Vandenplas, Olivier, additional, Ventura, Maria Teresa, additional, Vichyanond, Pakit, additional, Wagenmann, Martin, additional, Wallace, Dana, additional, Walusiak‐Skorupa, Jolanta, additional, Wang, De Yun, additional, Waserman, Susan, additional, Wong, Gary WK, additional, Yorgancioglu, Arzu, additional, Yusuf, Osman M, additional, Zernotti, Mario, additional, Zhang, Luo, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, and Jutel, Marek, additional

Published
2021
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14. Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects model

Author

Bernardo Sousa‐Pinto, Luís Filipe Azevedo, Ana Sá‐Sousa, Rafael José Vieira, Rita Amaral, Ludger Klimek, Wienczyslawa Czarlewski, Josep M. Anto, Anna Bedbrook, Violeta Kvedariene, Maria Teresa Ventura, Ignacio J. Ansotegui, Karl‐Christian Bergmann, Luisa Brussino, G. Walter Canonica, Victoria Cardona, Pedro Carreiro‐Martins, Thomas Casale, Lorenzo Cecchi, Tomás Chivato, Derek K. Chu, Cemal Cingi, Elisio M. Costa, Alvaro A. Cruz, Giulia De Feo, Philippe Devillier, Wytske J. Fokkens, Mina Gaga, Bilun Gemicioğlu, Tari Haahtela, Juan Carlos Ivancevich, Zhanat Ispayeva, Marek Jutel, Piotr Kuna, Igor Kaidashev, Helga Kraxner, Désirée E. Larenas‐Linnemann, Daniel Laune, Brian Lipworth, Renaud Louis, Michaël Makris, Riccardo Monti, Mario Morais‐Almeida, Ralph Mösges, Joaquim Mullol, Mikaëla Odemyr, Yoshitaka Okamoto, Nikolaos G. Papadopoulos, Vincenzo Patella, Nhân Pham‐Thi, Frederico S. Regateiro, Sietze Reitsma, Philip W. Rouadi, Boleslaw Samolinski, Milan Sova, Ana Todo‐Bom, Luis Taborda‐Barata, Peter Valentin Tomazic, Sanna Toppila‐Salmi, Joaquin Sastre, Ioanna Tsiligianni, Arunas Valiulis, Dana Wallace, Susan Waserman, Arzu Yorgancioglu, Mihaela Zidarn, Torsten Zuberbier, João Almeida Fonseca, Jean Bousquet, and Oliver Pfaar

Subjects
allergic rhinitis, immunotherapy, mobile health, patient‐reported outcomes, real‐life data analysis, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real‐life studies. Objective To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK‐air® app: those receiving sublingual AIT (SLIT), those receiving subcutaneous AIT (SCIT), and those receiving no AIT. Methods We assessed the MASK‐air® data of European users with self‐reported grass pollen allergy, comparing the data reported by patients receiving SLIT, SCIT and no AIT. Outcome variables included the daily impact of allergy symptoms globally and on work (measured by visual analogue scales—VASs), and a combined symptom‐medication score (CSMS). We applied Bayesian mixed‐effects models, with clustering by patient, country and pollen season. Results We analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT‐tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = −12.1;−2.8), lower VAS Work (average difference = 5.0; 95%CrI = −8.5;−1.5), and a lower CSMS (average difference = 3.7; 95%CrI = −9.3;2.2). When compared to SCIT, SLIT‐tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = −17.2;−2.8), lower VAS Work (average difference = 7.8; 95%CrI = −15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = −18.5;0.2). Conclusion In patients with grass pollen allergy, SLIT‐tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally‐harmonised standards for performing and reporting real‐world data in AIT are needed to better understand its ‘real‐world’ effectiveness.

Published
2022
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