1. Immunoglobulin G Subclass Response to a Meningococcal Quadrivalent Polysaccharide-Diphtheria Toxoid Conjugate Vaccine
- Author
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Robert S. Heyderman, Helen Findlow, Elizbeth Miller, Paul Balmer, Cressida Auckland, Lesley Mabey, Jo Southern, Ray Borrow, and Rhonwen Morris
- Subjects
Adult ,Microbiology (medical) ,Blood Bactericidal Activity ,Diphtheria Toxoid ,Clinical Biochemistry ,Immunology ,Meningococcal Vaccines ,Neisseria meningitidis ,Subclass ,Serology ,Serum Bactericidal Antibody Assay ,Conjugate vaccine ,Humans ,Immunology and Allergy ,Medicine ,Diphtheria toxin ,Vaccines, Conjugate ,business.industry ,Polysaccharides, Bacterial ,Middle Aged ,Vaccine Research ,Antibodies, Bacterial ,Virology ,Vaccination ,Immunization ,Immunoglobulin G ,business ,Conjugate - Abstract
Changes in the immunoglobulin G1 (IgG1)/IgG2 ratio following vaccination can indicate the activation of cellular control mechanisms typical of a T-cell-dependent response. We examined IgG subclass ratios in 17 healthy adults (26 to 55 years of age) before and 4 to 6 weeks following immunization with a quadrivalent meningococcal-polysaccharide diphtheria toxoid conjugate vaccine against serogroups A, C, Y, and W135. Serologic responses were determined by serum bactericidal antibody assay and serogroup-specific IgG, IgG1, and IgG2 enzyme-linked immunosorbent assay. Prevaccination serogroup A-specific IgG1/IgG2 ratios were
- Published
- 2006
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