1. Delta-aminolevulinate dehydratase (delta-ALA-D) activity in diabetes and hypothyroidism.
- Author
-
Souza JB, Rocha JB, Nogueira CW, Borges VC, Kaizer RR, Morsch VM, Dressler VL, Martins AF, Flores EM, and Schetinger MR
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Blood Glucose metabolism, Case-Control Studies, Copper blood, Female, Glycated Hemoglobin metabolism, Humans, Male, Middle Aged, Thyrotropin blood, Zinc blood, Diabetes Mellitus, Type 2 blood, Hypothyroidism blood, Porphobilinogen Synthase blood
- Abstract
Objectives: This study analyzed the influence of type 2 diabetes mellitus and primary hypothyroidism on the activity of the delta-aminolevulinate dehydratase (delta-ALA-D) in human blood., Design and Methods: Delta-ALA-D enzyme activity was determined in normal (healthy) people (n=29), compensated (DMC, n=11) and non-compensated diabetic patients (NDMC, n=23), and in patients with compensated (CH, n=19) and non-compensated primary hypothyroidism (NCH, n=10). The determination of lead, copper, zinc and magnesium was performed by graphite furnace atomic absorption spectrometry., Results: This study shows that delta-ALA-D activity was decreased (P<0.05) in situations associated to hyperglycemia maintained for long periods (HbA1c high). Another finding of this study suggests that states of hypofunction of the thyroid gland, when non-compensated, increase the activity of delta-ALA-D (P<0.001). In addition, copper was elevated in HNC, zinc was diminished in DMC, HC and HNC, and magnesium was diminished in the HNC group., Conclusion: This result points out that there is a correlation among diabetes, hypothyroidism and delta-ALA-D activity.
- Published
- 2007
- Full Text
- View/download PDF