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Start Over Author "Di Resta C." Journal clinical biochemistry
4 results on '"Di Resta C."'

3. New molecular approaches to Alzheimer's disease

Author

Maurizio Ferrari, Chiara Di Resta, Di Resta, C., and Ferrari, M.

Subjects
Big Data, Epigenomics, Proteomics, Gerontology, 030213 general clinical medicine, Genetic risk loci, Clinical Biochemistry, Disease, 030204 cardiovascular system & hematology, Medical care, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Humans, Metabolomics, Medicine, Dementia, Diagnostic, Risk factor, Clinical implication, business.industry, High-Throughput Nucleotide Sequencing, General Medicine, Alzheimer's disease, Omics, Precision medicine, medicine.disease, Omics sciences, Older people, business, AD pathogenesi
Abstract

Alzheimer's disease is a neurodegenerative disorder and the most common and devastating form of dementia. It affects mainly older people, accounting for 50-80% of dementia cases. The age is the main associated risk factor and based on the onset age, early-onset (EOAD) or late-onset (LOAD) forms are distinguished. AD has a strong impact both on the life-style of patients and their families and on the society, due to the high costs related to social and medical care. So far, despite the great advances in understanding of the AD pathogenesis, there is no a cure for this form of dementia and current available treatments are limited to temporarily relieve symptoms. In this review, firstly we give an overview of the current knowledge of the genetic basis of both forms of AD with a particular emphasis on the insights in the understanding of the pathogenic mechanisms of this disorder. Then we discuss the promising relevance of "omics sciences" and the open challenges of the application of Big Data in promoting precision medicine for AD.

Published
2019
Full Text
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4. New molecular approaches to Alzheimer's disease.

Author

Di Resta C and Ferrari M

Subjects
Alzheimer Disease physiopathology, Big Data, Epigenomics statistics & numerical data, High-Throughput Nucleotide Sequencing, Humans, Metabolomics statistics & numerical data, Proteomics statistics & numerical data, Alzheimer Disease genetics
Abstract

Alzheimer's disease is a neurodegenerative disorder and the most common and devastating form of dementia. It affects mainly older people, accounting for 50-80% of dementia cases. The age is the main associated risk factor and based on the onset age, early-onset (EOAD) or late-onset (LOAD) forms are distinguished. AD has a strong impact both on the life-style of patients and their families and on the society, due to the high costs related to social and medical care. So far, despite the great advances in understanding of the AD pathogenesis, there is no a cure for this form of dementia and current available treatments are limited to temporarily relieve symptoms. In this review, firstly we give an overview of the current knowledge of the genetic basis of both forms of AD with a particular emphasis on the insights in the understanding of the pathogenic mechanisms of this disorder. Then we discuss the promising relevance of "omics sciences" and the open challenges of the application of Big Data in promoting precision medicine for AD., (Copyright © 2019 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.)

Published
2019
Full Text
View/download PDF

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