1. Probody Therapeutic Design of
- Author
-
Danique, Giesen, Linda N, Broer, Marjolijn N, Lub-de Hooge, Irina, Popova, Bruce, Howng, Margaret, Nguyen, Olga, Vasiljeva, Elisabeth G E, de Vries, and Martin, Pool
- Subjects
Male ,Radioisotopes ,Antibodies, Monoclonal ,Xenograft Model Antitumor Assays ,B7-H1 Antigen ,Mice ,Cell Line, Tumor ,Drug Design ,Neoplasms ,Positron-Emission Tomography ,Tumor Microenvironment ,Animals ,Autoradiography ,Humans ,Tissue Distribution ,Zirconium ,Radiopharmaceuticals ,Immune Checkpoint Inhibitors - Abstract
Probody therapeutic CX-072 is a protease-activatable antibody that is cross-reactive with murine and human programmed death-ligand 1 (PD-L1). CX-072 can be activatedPET imaging revealed
- Published
- 2019