1. Myocardial perfusion profile in a young population with and without known coronary artery disease: comparison by gender
- Author
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Alexander Battler, Nili Zafrir, Jaqueline Sulkes, Alejandro Solodky, Ran Kornowski, and Israel Mats
- Subjects
Adult ,Male ,Technetium Tc 99m Sestamibi ,medicine.medical_specialty ,Vasodilator Agents ,Population ,Ischemia ,Myocardial Ischemia ,Clinical Investigations ,Coronary Artery Disease ,Risk Assessment ,High cholesterol ,Angina ,Coronary artery disease ,Myocardial perfusion imaging ,Sex Factors ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Coronary Circulation ,medicine ,Humans ,cardiovascular diseases ,Thallium ,education ,ST depression ,Tomography, Emission-Computed, Single-Photon ,education.field_of_study ,Chi-Square Distribution ,medicine.diagnostic_test ,business.industry ,Age Factors ,Myocardial Perfusion Imaging ,General Medicine ,Dipyridamole ,Middle Aged ,medicine.disease ,Logistic Models ,Cardiology ,Female ,medicine.symptom ,Radiopharmaceuticals ,Cardiology and Cardiovascular Medicine ,business ,Echocardiography, Stress - Abstract
Background More and more young people are being referred for evaluation or screening for coronary artery disease (CAD). However, the value of myocardial perfusion imaging (MPI) in this population is unclear, especially in the absence of symptoms. Methods The study sample included 1765 consecutive patients less than 51 years old who were referred to a major medical center for stress/rest MPI study. Clinical and MPI variables were compared between patients with and without known CAD, by gender. Results There were 1346 (76%) men and 419 (24%) women of mean age 44 ± 6 years; 461 (26%) had known CAD. Stress-induced ischemia was detected in 321 patients (18.2%) and significant ischemia in 131 (7.4%); there was no difference in the rate or severity of ischemia by presence of symptoms. Among those without known CAD, the rate of stress-induced ischemia by MPI was significantly lower in women than men. On logistic regression analysis, the independent predictors of ischemia in men were high cholesterol, diabetes, angina during stress testing, ST depression, and smoking (P
- Published
- 2010