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Autologous hematopoietic cell transplantation following induction therapy is standard of care for most patients with newly diagnosed multiple myeloma (N Engl J Med 2017, 376; 1311). Though active COVID‐19 infection is typically a contraindication to aggressive therapy, little is known about the safety of autologous transplantation after resolution of acute symptoms and undetectable pathogen by nasopharyngeal PCR., The majority of patients with underlying hematologic malignancy will survive acute COVID‐19 infection. For many, subsequent dose‐intensive therapy with autologous transplantation will be critical for optimal outcomes, and those with clinical recovery from COVID‐19 infection should not be precluded from consideration of autologous hematopoietic cell transplantation.

An abnormal clinical Allen's test is not a definitive exclusion criterion for free radial forearm flap use. A surgical Allen's test may be useful to determine whether flap harvest is feasible in patients with an abnormal clinical Allen's test.

Thrombocytopenia is a rare but possible complication of appendicitis and, if severe, might be a contraindication to appendectomy.

In complex calcified LM lesions, RA is an effective and safe alternative for resolving stenosis. As a plaque modifier, RA can allow an optimal stent deployment. Nevertheless, in limited availability of intravascular imaging, well‐preparedness against incidental angiography findings is mandatory. Distal aneurysm is not a contraindication provided that the team has the necessary experience.

Key Clinical Message Clamshell thoracotomy (CST) may be indicated and life‐saving in carefully selected cases of blunt trauma. As such, the current clinical stance of general contraindication of CST in blunt trauma should be reviewed and criteria developed to accommodate select cases, considering the diversity of injuries resulting from blunt trauma.

Key Clinical Message A female with massive PTE and absolute contraindication for thrombolytic did not meet guidelines due to unavailability of catheter or surgical embolectomy and giving thrombolytic as a last resort to save a life. In such cases, physicians should consider to act outside of the guidelines to save a life.

Key Clinical Message The use of excimer laser with contrast for treating an underexpanded stent in the setting of subacute stent thrombosis and hemodynamic instability is described. The patients presented with acute coronary syndromes and cardiogenic shock resulting from stent thrombosis of underexpanded stents. The stents were recalcitrant to aggressive balloon dilation and in the setting of an acute myocardial infarction; rotational atherectomy is a relative contraindication. The use of concurrent contrast during laser atherectomy resulted in plaque modification and subsequent stent expansion.

Primary immune thrombocytopenia (pITP) is an autoimmune disorder characterized either by an increased peripheral platelets clearance or by a decreased platelets production. The goal of pITP therapy is to reach and maintain a safe platelet level to avoid bleedings. International guidelines recommend corticosteroids and/or high‐dose immunoglobulin as first‐line treatment, while splenectomy as a second‐line therapy. In case of contraindication or refractoriness to splenectomy, rituximab or other immunosuppressants and the new thrombopoietin receptor agonists (TPO‐RAs), romiplostim and eltrombopag, are considered alternative treatments 1, 2. In Europe, TPO‐RAs have been approved by EMA for the treatment of chronic pITP patients unresponsive to other therapies.

Carotid body paraganglioma is commonly asymptomatic, slow‐growing, and nonfunctioning. With its relative contraindication to biopsy due to its high vascularity in nature, imaging characteristics are the key to help making the diagnosis. Treatment modalities, ranging from an observation to definitive treatment with surgery, should be selected on an individual basis.

Department of Paediatrics, The University of the West Indies, St. Augustine, Eric Williams Medical Sciences Complex, Uriah Butler Highway,Champ Fleurs, Trinidad and TobagoCorrespondenceSameer Dhingra, School of Pharmacy, Facultyof Medical Sciences, The University of theWest Indies, St. Augustine, Eric WilliamsMedical Sciences Complex, Uriah ButlerHighway, Champ Fleurs, Trinidad andTobago. Tel. +1 868 645 2640 Ext. 5005;Fax: +1 868 662 1472; E-mail:sameer.dhingra@sta.uwi.eduFunding InformationNo funding information provided.Received: 11 June 2014; Revised: 2 July2014; Accepted: 2 July 2014doi:10.1002/ccr3.106