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Start Over Author "Ivana Lagreca" Journal clinical case reports
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1. All‐trans retinoic acid (ATRA) in non‐promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low‐dose Ara‐C in three elderly patients with NPM1 ‐mutated AML unfit for intensive chemotherapy and review of the literature

Author

Elisabetta Colaci, Ivana Lagreca, Brunangelo Falini, Giovanni Riva, Maria Paola Martelli, Roberto Marasca, Leonardo Potenza, Franco Narni, Chiara Quadrelli, Sergio Amadori, Ambra Paolini, Adriano Venditti, Patrizia Barozzi, Fabio Forghieri, Sara Bigliardi, Mario Luppi, Francesco Lo Coco, Patrizia Zucchini, Daniela Vallerini, and Monica Morselli

Subjects
0301 basic medicine, Oncology, NPM1, medicine.medical_specialty, business.industry, Low dose, All trans, Retinoic acid, Myeloid leukemia, General Medicine, Intensive chemotherapy, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, Internal medicine, Flt3 mutation, Medicine, business
Abstract

Based upon the clinical behavior of three patients, we suggest that the combination of low-dose Ara-C and all-trans retinoic acid may potentially be effective in some elderly patients, unfit for intensive chemotherapy, affected with NPM1-mutated acute myeloid leukemia without FLT3 mutations, warranting perspective clinical studies in these selected patients.

Published
2016
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