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Start Over Author "Esposito, Carmela" Journal clinical chemistry & laboratory medicine
1 results on '"Esposito, Carmela"'

1. Comparison of the TaqMan and LightCycler systems in pharmacogenetic testing: evaluation of CYP2C9*2/*3 polymorphisms.

Author

Toriello, Mario, Meccariello, Pasquale, Mazzaccara, Cristina, Di Fiore, Rosanna, Esposito, Carmela, and Sacchetti, Lucia

Subjects
PHARMACOGENOMICS, DRUG metabolism, ENZYMES, GENETIC polymorphisms, MEDICAL equipment, CLINICAL medicine
Abstract

Background: Pharmacogenetic testing for drug-metabolizing enzymes is not yet widely used in clinical practice. Methods: In an attempt to facilitate the application of this procedure, we have compared two real-time PCR-based methods, the TaqMan® and the LightCycler™ for the pharmacogenetic evaluation of CYP2C9*2/*3 polymorphisms. Results and Conclusion: Both procedures are suitable for pharmacogenetic studies. The TaqMan procedure was less expensive in terms of cost per sample, but the TaqMan apparatus is more expensive than the LightCycler apparatus. [ABSTRACT FROM AUTHOR]

Published
2006
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