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Your search keyword '"Varga, József"' showing total 5 results
Start Over Author "Varga, József" Journal clinical chemistry and laboratory medicine
5 results on '"Varga, József"'

5. Age dependence of serum beta-N-acetylhexosaminidase (NAG) activity.

Author

Oláh AV, Price RG, Csáthy L, Országh E, Oláh E, and Varga J

Subjects
Acetylglucosamine chemistry, Acetylglucosamine metabolism, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Catalysis, Child, Child, Preschool, Clinical Enzyme Tests methods, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Reference Values, Spectrum Analysis, Statistical Distributions, Thiazoles chemistry, Thiazoles metabolism, Acetylglucosamine analogs & derivatives, beta-N-Acetylhexosaminidases blood
Abstract

Serum N-acetyl-beta-D-glucosaminidase (NAG; EC 3.2.1.30) is a hexosaminidase and may be a predictor of vascular injury, e.g., in infant respiratory distress syndrome, pneumonia, broncho-pulmonary dysplasia and necrotizing enterocolitis. To estimate the new diagnostic prospects we have modified our urinary NAG assay. In this sensitive colorimetric micro-assay, VRA-GlcNAc was used as a substrate. In the present study the age dependence of serum NAG activity was investigated in newborn babies, infants (1-24 months), children (2-18 years) and adults (19-80 years). Serum NAG activity was found to be age-dependent; it is higher in early childhood (11-59 U/l) but decreases to a constant value at the age of 1-2 years. After the age of 2 years it is similar to adults' NAG (10-30 U/l). In pediatrics age-matched reference ranges must be taken into consideration.

Published
2004
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