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Your search keyword '"Aldosterone renin"' showing total 2 results
Start Over Descriptor "Aldosterone renin" Journal clinical endocrinology
2 results on '"Aldosterone renin"'

1. Rates of abnormal aldosterone/renin ratio in African-origin compared to European-origin patients: A retrospective study

Author

Lucy Ann Behan, Sorresa Abadi, Delia Bogdanet, Gerald Boran, Mark Sherlock, James Gibney, Khalid Mohamed Saeed Ahmed, Conor Woods, and Rosemary Dineen

Subjects
Adult, Male, Aldosterone renin, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Hypokalemia, 030209 endocrinology & metabolism, Gastroenterology, African origin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Internal medicine, Hyperaldosteronism, Renin, Renin–angiotensin system, Humans, Medicine, Adrenal adenoma, Aldosterone, Retrospective Studies, business.industry, Retrospective cohort study, Hyperplasia, medicine.disease, chemistry, Echocardiography, 030220 oncology & carcinogenesis, Africa, Hypertension, Female, business
Abstract

INTRODUCTION The aldosterone/renin ratio is the initial screening test for primary hyperaldosteronism (PHA), but little data exists regarding ethnic variations in this. METHODS Following clinical observation of a high prevalence of abnormal aldosterone/renin ratio (ARR) in patients of African-origin, we retrospectively reviewed all ARR measurements in a single centre over 10 years. Rates of hypokalaemia, intraventricular septal thickness (IVS, by echocardiography) and adrenal imaging were recorded when available. RESULTS Aldosterone/renin ratio was available in 1473 patients, and abnormal in 374 (25.4%). Abnormal ARR was observed in 305/1349 (22.6%) of European-origin and 69/124 (55.6%) of African-origin patients (P

Published
2019
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2. Positive association between aldosterone-renin ratio and carotid intima-media thickness in hypertensive children

Author

Carlos E. Fardella, Carolina Loureiro, Cristian A. Carvajal, Rodrigo Bancalari, Carmen Campino, Iván Godoy, Marlene Aglony, Hernán García, and Alejandro Martinez-Aguayo

Subjects
Male, medicine.medical_specialty, Aldosterone renin, Adolescent, Endocrinology, Diabetes and Metabolism, Plasma renin activity, Carotid Intima-Media Thickness, chemistry.chemical_compound, Endocrinology, Internal medicine, medicine.artery, Renin–angiotensin system, Renin, medicine, Humans, Brachial artery, Child, Aldosterone, business.industry, chemistry, Intima-media thickness, Hypertension, Female, Cortisone, business, Glucocorticoid, medicine.drug
Abstract

ummaryIntroduction From an early age, hypertension can damage blood vessels through multiple mechanisms. The aim of this study was to evaluate the presence of vascular damage and whether it is associated with the mineralo- and glucocorticoid profiles of hypertensive children. Subjects and methods We studied 64 hypertensive children. Anthropometric parameters and serum aldosterone (SA), plasma renin activity (PRA), aldosterone/renin ratio (ARR), cortisol (F) and cortisone (E) were measured. The serum F/E ratio was calculated to estimate the activity of the enzyme 11β-HSD2. Vascular damage was determined by carotid intima-media thickness (cIMT) and flow-mediated dilation of the brachial artery (FMD) on ultrasound. Results (median; Q1–Q3) Of the patients observed, 39% were females, and the median value for age (years) was 11·2 (9·1–13·3), for BMI (SDS) was 1·36 (0·84–1·80), for body fat mass (%) was 28·3 (17·8–36·0), for SBP index was 1·17 (1·12–1·25) and for the DBP index was 1·27 (1·16–1·36). Measurements revealed an SA level higher than 491 pmol/l in 4/64 patients, a PRA value lower than 0·5 ng/ml/h in 2/64, an ARR higher than 10 in 3/64 and serum F/E ratio higher than 4·3 in 10/64. The median brachial FMD (%) was 8·41 (5·61–10·91), and the median cIMT (mm) was 0·40 (0·37–0·43). The ARR was the only variable that explained changes in cIMT (β = 0·571, R2 = 0·315, P

Published
2012

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