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Summary: Objectives: A population‐based study was undertaken to determine the mortality and morbidity for people with hypoparathyroidism compared to the general population. Methods: In this study, patients identified with chronic hypoparathyroidism using data linkage from regional datasets were compared with five age‐ and gender‐matched controls from the general population. Data from biochemistry, hospital admissions, prescribing and the demographic dataset were linked. Outcomes for mortality and specified conditions were examined for all patients and subdivided into post‐surgical and non‐surgical cases of hypoparathyroidism. Results: All patients had an increased risk of epilepsy (HR 1.65 [95% CI 1.12‐2.44]) and cataracts (HR 2.10 [1.30‐3.39]) but no increased fracture risk. Only non‐surgical hypoparathyroid patients also had increased mortality (HR 2.11 [1.49‐2.98]), cardiovascular disease (HR 2.18 [1.41‐3.39]), cerebrovascular disease (HR 2.95 [1.46‐5.97]), infection (HR 1.87 [1.2‐2.92]) and mental illness (HR 1.59 [1.21‐2.11]). There was an increased risk of renal failure (HR 10.05 [95% CI 4.71‐21.43]) during the first 2000 days (5.5 years) of follow‐up. Renal failure and death were associated with increasing serum calcium concentrations. Conclusion: Patients with hypoparathyroidism have an increased risk of cataract and epilepsy. Non‐surgical hypoparathyroidism is associated with increased mortality and additional morbidities. [ABSTRACT FROM AUTHOR]

Objective To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT). Design Retrospective population-based observational study. Setting Tayside, Scotland, from 1997 to 2006. Participants Patients with mild PHPT were selected from a predefined PHPT cohort between 1997 and 2006. Main outcome measures Standardised mortality ratios (SMRs) were examined for all-cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co-morbidities. Results In total, there were 1683 (69·1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all-cause mortality and cardiovascular mortality (SMR-all cause 2·62, 95% CI 2·39–2·86; SMR-cardiovascular 2·68, 95% CI 2·34–3·05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age- and sex-adjusted general population. Conclusions Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT. [ABSTRACT FROM AUTHOR]