1. Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci
- Author
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Jenny van Dongen, Tellervo Korhonen, Anu Loukola, Rachel F. Tyndale, Richa Gupta, Yu Fu, Jaakko Kaprio, Dorret I. Boomsma, Vidya Velagapudi, Miina Ollikainen, Abdel Abdellaoui, Biological Psychology, APH - Mental Health, APH - Personalized Medicine, APH - Methodology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Institute for Molecular Medicine Finland, University Management, Department of Public Health, Clinicum, University of Helsinki, Department of Pathology, Medicum, HUS Abdominal Center, Epigenetics of Complex Diseases and Traits, and Genetic Epidemiology
- Subjects
BIOMARKER ,Netherlands Twin Register (NTR) ,Epigenomics ,Male ,0301 basic medicine ,BLOOD ,ACCURACY ,lcsh:Medicine ,PATHWAY ,Cytochrome P-450 CYP2A6 ,Nicotine ,chemistry.chemical_compound ,0302 clinical medicine ,Genotype ,Cotinine ,Genetics (clinical) ,Smoking ,Methylation ,Middle Aged ,Genetic risk score ,3. Good health ,CpG site ,030220 oncology & carcinogenesis ,DNA methylation ,Female ,CIGARETTE SMOKERS ,medicine.drug ,Adult ,medicine.medical_specialty ,lcsh:QH426-470 ,3122 Cancers ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Nicotine metabolism ,Young Adult ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Epigenome-wide association study ,SELF-REPORTED SMOKING ,meQTL ,Internal medicine ,Genetics ,medicine ,Humans ,Epigenetics ,Molecular Biology ,Genetic Association Studies ,Aged ,Research ,lcsh:R ,DIFFERENTIAL DNA METHYLATION ,NICOTINE METABOLITE RATIO ,DNA Methylation ,lcsh:Genetics ,Molecular mediation ,030104 developmental biology ,Endocrinology ,chemistry ,CpG Islands ,CESSATION ,3111 Biomedicine ,LUNG ,Causal inference ,Developmental Biology - Abstract
Background DNA methylation alteration extensively associates with smoking and is a plausible link between smoking and adverse health. We examined the association between epigenome-wide DNA methylation and serum cotinine levels as a proxy of nicotine exposure and smoking quantity, assessed the role of SNPs in these associations, and evaluated molecular mediation by methylation in a sample of biochemically verified current smokers (N = 310). Results DNA methylation at 50 CpG sites was associated (FDR
- Published
- 2019
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