1. MicroRNAs overexpressed in Crohn’s disease and their interactions with mechanisms of epigenetic regulation explain novel aspects of Crohn’s disease pathogenesis
- Author
-
Roberto Navarro Quiroz, Sandra Hernández Agudelo, Anderson Díaz Pérez, Antonio Acosta Hoyos, Andres Cadena Bonfanti, Cecilia Fernández-Ponce, Gustavo Aroca Martínez, Elkin Navarro Quiroz, Alberto Espinoza Garavito, José Rafael Consuegra Machado, Francisco García-Cózar, Lorena Gomez Escorcia, Linda Atencio Ibarra, Christian Orozco Sánchez, José Villarreal Camacho, and Biomedicina, Biotecnología y Salud Pública
- Subjects
CD4-Positive T-Lymphocytes ,Crohn’s disease ,0301 basic medicine ,Crohn’ ,Epigenetic mechanisms ,T cells ,Review ,Biology ,medicine.disease_cause ,Epigenesis, Genetic ,s disease ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Crohn Disease ,Downregulation and upregulation ,Gene expression ,microRNA ,Genetics ,medicine ,Humans ,Protein Interaction Maps ,Epigenetics ,Molecular Biology ,Genetics (clinical) ,Regulation of gene expression ,Immunity ,MicroRNA ,DNA Methylation ,Chromatin Assembly and Disassembly ,Chromatin ,Cell biology ,MicroRNAs ,030104 developmental biology ,Gene Expression Regulation ,030220 oncology & carcinogenesis ,CpG Islands ,Carcinogenesis ,Protein Processing, Post-Translational ,Post-translational modifications ,Developmental Biology - Abstract
Background In this review, we were interested to identify the wide universe of enzymes associated with epigenetic modifications, whose gene expression is regulated by miRNAs with a high relative abundance in Crohn's disease (CD) affected tissues, with the aim to determine their impact in the pathogenesis and evolution of the disease. Methods We used HMDD and Bibliometrix R-package in order to identify the miRNAs overexpressed in CD. The identified enzymes associated with epigenetic mechanisms and post-translational modifications, regulated by miRNAs upregulated in CD, were analyzed using String v11 database. Results We found 190 miRNAs with great abundance in patients with CD, of which 26 miRNAs regulate the gene expression of enzymes known to catalyze epigenetic modifications involved in essentials pathophysiological processes, such as chromatin architecture reorganization, immune response regulation including CD4+ T cells polarization, integrity of gut mucosa, gut microbiota composition and tumorigenesis. Conclusion The integrated analysis of miRNAs with a high relative abundance in patients with CD showed a combined and superimposed gene expression regulation of enzymes associated with relevant epigenetic mechanisms and that could explain, in part, the pathogenesis of CD.
- Published
- 2021
- Full Text
- View/download PDF